Relationship Between Serum TAP,proGRP,cyfra21-1 and Curative Effect of Neoadjuvant Chemotherapy,Prognosis in Stage Ⅲ～Ⅳ NSCLC
Objective To explore the relationship between serum tumor abnormal protein(TAP),gastrin releasing pep-tide precursor(proGRP),cytokeratin 19 fragment(cyfra21-1)and curative effect of neoadjuvant chemotherapy(NCT),prognosis in stage Ⅲ～Ⅳ non-small cell lung cancer(NSCLC).Methods 100 patients with stage Ⅲ～Ⅳ NSCLC undergoing NCT were enrolled as the research objects.According to different curative effect,they were divided into effective group and ineffective group.The levels of TAP,proGRP and cyfra21-1 in the 2 groups were compared before and after chemotherapy.The evaluation value of TAP,proGRP and cyfra21-1 for curative effect of NCT was analyzed.All patients were followed up for 1 year to analyze the rela-tionship between TAP,proGRP,cyfra21-1 and prognosis after chemotherapy.Results After chemotherapy,levels of TAP,proGRP and cyfra21-1 in effective group were lower than those in ineffective group(P＜0.05).The results of ROC curves analysis showed that AUC and cut-off values of TAP,proGRP and cyfra21-1 for evaluating curative effect of NCT were(0.739,178.18 μm2),(0.810,52.21ng/L)and(0.775,7.70μmol/L),respectively.AUC of combined detection was 0.913,greater than that of single index(P＜0.05).The 1-year survival rates in patients with high expressions of TAP,proGRP and cyfra21-1 were lower than those with low expressions(P＜0.05).Conclusion TAP combined with proGRP and cyfra21-1 has high evaluation value for curative effect of NCT in patients with stage Ⅲ～Ⅳ NSCLC,and the three indexes are all closely related to prognosis.
万方数据
维普
