Expression of VEGFR2,miR-21,UCP1,and UCP3 in Non-small Cell Lung Cancer Tissue and Their Correlation with Prognosis
Objective To analyze the expression of vascular endothelial growth factor receptor 2(VEGFR2),microRNA-21(miR-21),uncoupling protein 1(UCP1),and uncoupling protein 3(UCP3)in non-small cell lung cancer(NSCLC)tissues and their correlation with prognosis.Methods 98 NSCLC patients were selected,and their cancer tissue and adjacent normal tissue were taken during surgery to detect the expression of VEGFR2,miR-21,UCP1,and UCP3;Analyze the relationship between the expression of VEGFR2,miR-21,UCP1,and UCP3 and their clinical pathological characteristics;Follow up for 1 year to analyze the relationship between the expression of VEGFR2,miR-21,UCP1,and UCP3 and patient survival rate.Results The positive expression rates of VEGFR2 and UCP1,as well as the relative expression levels of miR-21 in cancer tissue were higher than those in normal tissue adjacent to cancer,while the positive expression rate of UCP3 was lower than that in normal tissue adjacent to cancer,with statistical significance(P＜0.05);The expression of VEGFR2,miR-21,UCP1,and UCP3 is related to lymph node metastasis,clinical stage,and differentiation degree(P＜0.05);The 1-year survival rate of patients with positive expression of VEGFR2,UCP1,and high expression of miR-21 was lower than that of patients with negative expression of VEGFR2,UCP1,and low expression of miR-21,respectively.The 1-year survival rate of patients with positive expression of UCP3 was higher than that of patients with negative expression of UCP3,and the difference was statistically significant(P＜0.05).Conclusion VEGFR2,miR-21,UCP1,and UCP3 are abnormally expressed in NSCLC cancer tissue,which is closely related to the prognosis of patients.
万方数据
维普
