Objective To analyze the correlation between serum squamous cell carcinoma associated antigen(SCC-Ag),human epididymal secretory protein 4(HE4),SMAD4 and radiochemotherapy sensitivity of cervical cancer.Methods A total of 74 patients with cervical cancer underwent radiochemotherapy were enrolled as the research objects.According to radiochemother-apy sensitivity,they were divided into resistance group(48 cases)and sensitivity group(26 cases).The levels of serum SCC-Ag,HE4 and SMAD4 mRNA were detected before and after treatment,relation between levels of serum SCC-Ag,HE4 and SMAD4 and ultrasound parameters were analyzed,and their predictive value for radiochemotherapy sensitivity was evaluated by receiver operat-ing characteristic(ROC)curves.Results After treatment,mRNA levels of serum SCC-Ag and HE4 were decreased,while level of SMAD4 mRNA was increased in both groups(P＜0.05).Before and after treatment,levels of SCC-Ag and HE4 in sensitivity group were lower than those in resistance group,while level of SMAD4 mRNA was higher than that in resistance group(P＜0.05).Before treatment,levels of serum SCC-Ag and HE4 were positively correlated with Ⅵ(y=0.518,0.544,P＜0.05),while SMAD4 mRNA was negatively correlated with it(y=-0.581,P＜0.05).ROC curves analysis showed that predictive value of SCC-Ag combined with HE4 and SMAD4 was high for radiochemotherapy sensitivity(AUC=0.863(95％CI:0.764～0.962).Conclusion The levels of serum SCC-Ag,HE4 and SMAD4 mRNA are closely related to radiochemotherapy sensitivity of cervi-cal cancer,and combined detection has higher predictive value for radiochemotherapy sensitivity.
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