Level of TPSA,FPSA and Their Ratio in the Diagnosis of Prostate Cancer and Their Correlation with Biochemical Recurrence After Radical Prostatectomy
Objective To investigate the diagnostic value of serum total prostate-specific antigen(TPS A)and serum free prostate-specific antigen(FPS A)levels for prostate cancer and their correlation with biochemical recurrence after radical resec-tion.Methods 113 patients with prostate cancer(all underwent radical prostatectomy)were selected as the cancer group,100 patients with benign prostatic hyperplasia were selected as the hyperplasia group,and 78 healthy people in the same period were selected as the control group.The serum levels of TPSA and FPSA were detected in the cancer group,hyperplasia group and con-trol group before operation,and the FPSA/TPSA values were calculated to analyze the diagnostic value of TPSA,FPSA and FPSA/TPSA for prostate cancer;113 patients with prostate cancer were divided into biochemical recurrence group(31 cases)and non bi-ochemical recurrence group(82 cases)according to whether biochemical recurrence occurred after surgery.The clinicopathological factors of the 2 groups were collected and compared,and the correlation between biochemical recurrence after radical prostatecto-my and biochemical recurrence was analyzed by logistic regression.Results The levels of serum TPSA and FPSA in the cancer group were significantly higher than those in the hyperplasia group and the control group,the hyperplasia group was higher than that in the control group,and the fpsa/tpsa value was significantly lower than that in the hyperplasia group and the control group,and the hyperplasia group was lower than that in the control group(P＜0.05);ROC results showed that TPSA,TPS A,fPSA/TPS A had good sensitivity and specificity for the diagnosis of prostate cancer;There was no significant difference in age and body mass index between the 2 groups(P＞0.05).The positive rate of seminal vesicle invasion,positive rate of resection margin,positive rate of t2/t3 stage,Gleason score,serum TPSA and FPSA levels,and fpsa/tpsa value in the biochemical recurrence group were significantly higher than those in the non biochemical recurrence group(P＜0.05);Logistic regression analysis showed that semi-nal vesicle invasion,positive resection margin,aggravated pathological stage,high Gleason score,high levels of TPSA and FPSA,and low fpsa/tpsa ratio were high risk factors for biochemical recurrence after radical prostatectomy.Conclusion The levels of serum TPSA and FPSA in patients with prostate cancer were significantly increased,and the FPSA/TPSA ratio was significantly decreased.The detection of serum TPSA and FPSA levels combined with FPSA/TPSA ratio has high diagnostic value for prostate cancer,and can be used as a clinical screening method for prostate cancer.At the same time,the increase of serum TPSA and FP-SA levels and the decrease of FPSA/TPSA ratio are also high risk factors for biochemical recurrence after radical prostatectomy.
Prostate cancerSerum total prostate specific antigen(TPSA)Serum free prostate specific antigen(FPSA)FPSA/FPSABiochemical recurrence
万方数据
维普
