Changes and Clinical Significance of Th1/Th2 Cytokines and VEGFR After TACE in Patients with Primary Liver Cancer
Objective To explore the changes and clinical significance of Th1/Th2 cytokines and vascular endothelial growth factor receptor(VEGFR)in patients with primary liver cancer after transcatheter arterial chemoembolization(TACE).Methods 92 patients with primary liver cancer who received TACE treatment were selected.According to the treatment effect,the patients with complete remission or partial remission were included in effective group(n=50),and the patients with disease progression or disease stability were enrolled as ineffective group(n=42).General clinical data and serum Th1/Th2 cytokines[interleukin-2(IL-2),interleukin-4(IL-4),interleukin-18(IL-18)]and VEGFR before and after surgery were compared between the two groups of patients.Logistic regression model was used to analyze the correlation between the above indicators and efficacy.ROC curve was used to analyze the predictive efficiency of the above indicators after surgery on efficacy,and the differences in progression-free survival time were compared among patients with different levels of postoperative indicators.Results The levels of IL-2,IL-4 and VEGFR after surgery were decreased in both groups compared with those before surgery,and the levels in effec-tive group were significantly lower than those in ineffective group(P＜0.05).The level of IL-18 after surgery was significantly in-creased in both groups compared with that before surgery,and the level in effective group was significantly higher than that in inef-fective group(P＜0.05).IL-2,IL-4,IL-18 and VEGFR were significantly correlated with clinical efficacy(P＜0.05),ROC curves revealed that the AUCs of IL-2,IL-18 and VEGFR had evaluated value(P＜0.05),but the evaluated value of AUC of ROC curve of IL-4 was not high(P＞0.05).The mean progression-free survival time of patients with high level of IL-2 or VEGFR was significantly shorter than that of patients with low level of IL-2 or VEGFR(P＜0.05),and the progression-free survival time of patients with low level of IL-18 was significantly shorter than that of patients with high level of IL-18(P＜0.05).Conclusion Immune balance of Th1/Th2 cytokines in patients with primary liver cancer can be corrected after TACE,and VEGFR level is de-creased.Serum IL-2 and VEGFR level are closely related to efficacy and survival time,and can provide reference for clinical effi-cacy and prognosis evaluation.
万方数据
维普
