Diagnostic Value of US-FNA Combined with Serum CCL11 and HMGB1 in Lymph Node Metastasis of Papillary Thyroid Carcinoma
Objective To investigate the diagnostic value of ultrasound-guided fine needle aspiration cytology(US-FNA)combined with serum C-C motif chemokine 11(CCL11)and high-mobility group box 1(HMGB1)for lymph node metastasis in papillary thyroid carcinoma(PTC).Methods A total of 80 patients with PTC were selected(80 lymph nodes with ultrasound signs of suspicious metastatic lymph nodes).The patients were examined by US-FNA,and the serum levels of CCL11 and HMGB1 were detected.The surgical pathological examination results of all patients were counted.Using the results of surgical and patho-logical examination as the"gold standard",the detection of lymph node metastasis in PTC was observed by US-FNA.The levels of CCL11 and HMGB1 in serum of patients with PTC lymph node metastasis and those without metastasis were compared.Receiver operating characteristic(ROC)curve was used to analyze the diagnostic value of US-FNA combined with serum CCL11 and HMGB1 for lymph node metastasis in patients with PTC.Results The detection rate of lymph node metastasis in 80 lymph nodes was 88.75％(71/80)by surgical and pathological examination.Taking surgical and pathological examination results as the"gold standard",US-FNA detected 59 cases and missed 12 cases,the diagnostic sensitivity of lymph node metastasis was 83.10％(59/71)and a specificity of 100％(9/9)for the diagnosis of lymph node metastasis.The serum levels of CCL11 and HMGB1 in pa-tients with PTC lymph node metastasis were higher than those in patients without metastasis(P＜0.05).The ROC results showed that the optimal cut-off points of CCL11 and HMGB1 for the diagnosis of PCI lymph node metastasis were 63.04 pg/ml and 16.36 ng/ml,respectively,and the area under the curve(AUC)s were 0.851 and 0.814,respectively.The AUC for diagnosis was 0.901.Conclusion US-FNA combined with serum CCL11 and HMGB1 has high accuracy,sensitivity and specificity in the diag-nosis of PTC lymph node metastasis,and has high clinical application value.
Papillary thyroid carcinomaLymph node metastasisUltrasound-guided fine needle aspiration cytologyC-C motif chemokine 11High-mobility group box protein B1Diagnosis
万方数据
维普
