Relationship Between the Changes of Serum α-HBDH and CYFRA211 Levels and Clinical Stages and The Prognosis of Colorectal Cancer
Objective To investigate the relationship between the changes of serum α-hydroxybutyrate dehydrogenase(α-HBDH)and cytokeratin 19 fragment(CYFRA211)and clinical stages and the prognosis of colorectal cancer.Methods 152 patients with colorectal cancer were selected as the study group.At the same time,152 healthy individuals were selected as the control group.Serum α-HBDH and CYFRA211 levels in the 2 groups were compared.Serum α-HBDH and CYFRA211 levels in patients at TNM stage Ⅰ～Ⅳ were analyzed.Serum α-HBDH and CYFRA211 levels in patients with different prognosis were compared.The prognostic factors were analyzed.The relationship between serum indicators(α-HBDH and CYFRA211)and the prognosis was discussed.Results Serum α-HBDH and CYFRA211 levels in the study group were significantly higher than those in the control group(P＜0.05).As the tumor stage increased,α-HBDH level increased,with significant differences between dif-ferent stages(P＜0.05).There was no statistically significant difference in CYFRA211 level in stages Ⅰ～Ⅱ(P＞0.05).CY-FRA211 level was significantly higher in stage Ⅲ～Ⅳ,and were significantly higher in stage Ⅳ than in stage Ⅲ(P＜0.05).Un-ivariate analysis and multivariate regression analysis found that serum α-HBDH and CYFRA211 levels,and TNM staging were in-dependent influencing factors of the short-term prognosis(P＜0.05).The area under the receiver operating characteristic(ROC)curve values of serum α-HBDH and CYFRA211 levels to predict poor prognosis were 0.919 and 0.797.The specificity was 98.15％and 97.22％.The sensitivity was 81.82％and 65.91％(P＜0.05).Conclusion Serum α-HBDH and CYFRA211 levels in patients with colorectal cancer are relatively high,and are related to clinical stages and the short-term prognosis.The two are of certain value in predicting the short-term prognosis.
Colorectal cancer patientα-HBDHCYFRA211Clinical stagePrognosis
万方数据
维普
