摘要
目的 探讨程序性细胞死亡蛋白-1(PD-1)、程序性细胞死亡蛋白配体1(PD-L1)、T细胞免疫球蛋白粘蛋白-3(TIM-3)表达与食管癌患者的临床病理特征及预后的关系.方法 选取手术治疗的53例食管癌患者,术中取癌组织与癌旁正常组织,采用免疫组织化学法检测PD-1、PD-L1与TIM-3表达水平,并进行对比分析.进一步分析PD-1、PD-L1、TIM-3表达与食管癌患者临床病理特征及预后的关系.结果 癌组织中PD-1、PD-L1、TIM-3阳性表达率高于癌旁正常组织,有统计学差异(P＜0.05).PD-1、PD-L1、TIM-3表达与临床分期、淋巴结转移有关,有统计学差异(P＜0.05).PD-1、PD-L1、TIM-3阳性表达患者的3年生存率均低于阴性表达,有统计学差异(P＜0.05).结论 食管癌患者的癌组织内PD-1、PD-L1、TIM-3阳性表达率较高,三项指标与患者的临床分期、淋巴结转移联系紧密,且PD-1、PD-L1、TIM-3阳性表达患者的3年生存率更低,预后更差.
Abstract
Objective To investigate the relationship between the expression of Programmed cell death protein-1(PD-1),Programmed cell death protein ligand 1(PD-L1),T-cell immunoglobulin mucin-3(TIM-3)and the clinicopathological charac-teristics and prognosis of esophageal cancer patients.Methods 53 patients with esophageal cancer who underwent surgical treat-ment were selected.During the surgery,the expression levels of PD-1,PD-L1,and TIM-3 were detected using immunohistochemis-try between cancer tissue and normal adjacent tissues,and compared and analyzed;the relationship between the expression of PD-1,PD-L1,TIM-3 and the clinical pathological characteristics and prognosis of esophageal cancer patients were analyzed.Results The positive expression rates of PD-1,PD-L1,and TIM-3 in cancer tissues were higher than those in normal tissues adjacent to cancer,with statistical differences(P＜0.05);The expression of PD-1,PD-L1,and TIM-3 was correlated with clinical staging and lymph node metastasis,with statistical differences(P＜0.05).The 3-year survival rate of patients with positive expression of PD-1,PD-L1,and TIM-3 was lower than that of patients with negative expression,with statistical differences(P＜0.05).Conclusion The positive expression rates of PD-1,PD-L1,and TIM-3 in esophageal cancer tissues are relatively high,and the three indicators are closely related to the clinical stage and lymph node metastasis of patients.Moreover,patients with PD-1,PD-L1,and TIM-3 positive expression have a lower 3-year survival rate and poorer prognosis.
维普
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