The Relationship Between the Expression of PD-1,PD-L1,TIM-3 and the Clinical Pathological Characteristics and Prognosis of Esophageal Cancer
Objective To investigate the relationship between the expression of Programmed cell death protein-1(PD-1),Programmed cell death protein ligand 1(PD-L1),T-cell immunoglobulin mucin-3(TIM-3)and the clinicopathological charac-teristics and prognosis of esophageal cancer patients.Methods 53 patients with esophageal cancer who underwent surgical treat-ment were selected.During the surgery,the expression levels of PD-1,PD-L1,and TIM-3 were detected using immunohistochemis-try between cancer tissue and normal adjacent tissues,and compared and analyzed;the relationship between the expression of PD-1,PD-L1,TIM-3 and the clinical pathological characteristics and prognosis of esophageal cancer patients were analyzed.Results The positive expression rates of PD-1,PD-L1,and TIM-3 in cancer tissues were higher than those in normal tissues adjacent to cancer,with statistical differences(P＜0.05);The expression of PD-1,PD-L1,and TIM-3 was correlated with clinical staging and lymph node metastasis,with statistical differences(P＜0.05).The 3-year survival rate of patients with positive expression of PD-1,PD-L1,and TIM-3 was lower than that of patients with negative expression,with statistical differences(P＜0.05).Conclusion The positive expression rates of PD-1,PD-L1,and TIM-3 in esophageal cancer tissues are relatively high,and the three indicators are closely related to the clinical stage and lymph node metastasis of patients.Moreover,patients with PD-1,PD-L1,and TIM-3 positive expression have a lower 3-year survival rate and poorer prognosis.
Esophageal cancerProgrammed cell death protein-1Programmed cell death protein ligand 1T cell immu-noglobulin mucin-3Prognosis
万方数据
维普
