Diagnostic Value of Serum β2-MG,IL-17 and FLC Combined Detection in Early Renal Injury of Multiple Myeloma
Objective To investigate the diagnostic value of serumβ2 microglobulin(β2-MG),interleukin-17(IL-17)and serum free light chain(FLC)combined detection in early renal injury of multiple myeloma.Methods 80 patients with multiple myeloma were selected and divided according to whether there was early kidney injury.Patients with normal kidney function were included in the control group(n=40),and patients with abnormal kidney function were included in the observation group(n=40).Serumβ2-MG,IL-17 and FLC were detected in both groups,and the correlation between the three indexes was analyzed.Re-sults Serumβ2-MG(8.76±2.09)mg/L,IL-17(70.05±6.94)pg/ml,FLC-κ(1.97±0.35)mg/L,FLC-λ(2.41±0.61)mg/L,κ/λ(1.89±0.24)in the observation group were higher than those in the control group.The difference was statistically sig-nificant(P＜0.05).The detection values of β2-MG,IL-17,flc-K,FLC-λ and κ/λ in stage Ⅲ patients were higher than those in stage Ⅱ and stage Ⅰ patients in the observation group,with statistical significance(P＜0.05).The positive rate of β2-MG,IL-17 and FLC combined detection in the observation group was higher than that in the control group,and the positive rate of single de-tection was higher,the difference was statistically significant(P＜0.05).There was a positive correlation between β2-MG,IL-17 and FLC pairwise(P＜0.05).Conclusion The combination of serum β2-MG,IL-17 and FLC has a good value in predicting and diagnosing early renal injury in patients with multiple myeloma.
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