Effects of ff-IMRT and HT on Short-term and Long-term Efficacy and Side Effects in Patients with Cervical Cancer
Objective To explore the effects of fixed-field intensity modulated radiation therapy(ff-IMRT)and helical tomotherapy(HT)on short-term and long-term efficacy and side effects in patients with cervical cancer.Methods A retrospec-tive analysis was performed on the data of 60 patients with cervical cancer.According to different radiotherapy regimens,they were divided into IMRT group(ff-IMRT+synchronous chemotherapy,n=28)and HT group(HT+synchronous chemotherapy,n=32).The short-term and long-term efficacy,occurrence of side effects during treatment and the distribution of radiotherapy target dose were compared between the 2 groups.Results There was no significant difference in short-term efficacy between the 2 groups(P＞0.05).The conformal index of planning target in HT group was higher than that in IMRT group,homogeneity index and maximum target dose were lower than those in IMRT group(P＜0.05),and there was no significant difference in mean target dose between the 2 groups(P＞0.05).The incidence rates of gastrointestinal and urinary system side effects in HT group were 40.62％and 34.38％,lower than those in IMRT group(75.00％,67.86％,P＜0.05).There was no significant difference in re-currence or mortality between the two groups within 1 year(P＞0.05).Conclusion Both ff-IMRT and HT can better control dis-ease progression in patients with cervical cancer,without significant difference in overall efficacy.However,compared with ff-IM-RT,the radiation range is more homogeneous in HT treatment,which can reduce the maximum radiation dose while ensuring effi-cacy,minimize radiation damage to surrounding organs and tissues,and reduce radiotherapy-induced side effects,with relatively higher safety.
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