Clinical Characteristics and Prognosis of Patients with Multiple Myeloma and Myelofibrosis
Objective To explore the clinical characteristics and prognosis of patients with multiple myeloma(MM)and myelofibrosis.Methods A retrospective analysis was conducted on the clinical data of 83 MM patients,with 50 simple MM pa-tients as the control group and 33 MM patients with bone marrow fibrosis as the observation group.All patients underwent a chem-otherapy regimen based on bortezomib,and relevant data on disease staging,typing,and genetic characteristics were collected.The differences in efficacy,disease staging,typing,and genetic characteristics between the 2 groups were analyzed,and a 3-year follow-up was conducted to compare the differences in prognosis between the 2 groups.Results The effective rate of the observation group was lower than that of the control group,and the difference was statistically significant(P＜0.05).There was no statistically significant difference between the 2 groups in DS staging,ISS staging,and MM typing(P＞0.05);The positive rates of FISH,1 q21 amplification,D13S319 deletion,and IGH cleavage in the observation group were higher than those in the control group,with statistical significance(P＜0.05).The survival rate of the observation group was lower than that of the control group,and the difference was statistically significant(P＜0.05).Conclusion The clinical efficacy of patients with MM combined with bone marrow fibrosis is biased,prone to FISH,lq21 amplification,D13S319 deletion,and IGH breakage positivity,and the overall prog-nosis is poor.
万方数据
维普
