Predictive Value of A-Tg and Tg Reduction Index on the Efficacy of Postoperative First 131I Therapy in Patients with Low-to-moderate Risk Differentiated Thyroid Darcinoma
Objective To explore the predictive value of early thyroglobulin antibody(A-Tg)and thyroglobulin(Tg)re-duction index on the efficacy of postoperative 131I therapy in patients with low-to-moderate risk differentiated thyroid carcinoma(DTC).Methods The data of 108 patients with low-to-moderate risk differentiated DTC who received treatment were reviewed.All patients received radical resection of thyroid carcinoma+postoperative 131I therapy.Patients were divided into success group(88 cases)and failure group(20 cases)according to the efficacy of first 131I therapy.General data,A-Tg and Tg reduction index were compared among the patients.ROC curve and logistic regression analysis were used to analyze the predictive efficiency of the above indicators on the efficacy,and spearman correlation coefficient was used to analyze the relationship with efficacy.Results There were statistically significant differences in A-Tg,Tg reduction index,gender,tumor diameter and AJCC staging among pa-tients with different efficacies(P＜0.05),but there were no statistical differences in age,surgical method and therapeutic dose(P＞0.05).The AUCs of A-Tg,Tg reduction index and combined detection on predicting the prognosis were 0.755,0.844 and 0.882,and the sensitivities were 70.00％,90.00％and 90.00％,and the specificities were 77.27％,75.00％and76.14％re-spectively.Comparisons of A-Tg and Tg reduction index in patients with different efficacies showed statistical differences(P＜0.05).The higher A-Tg,the worse the efficacy,and the higher the Tg reduction index,the better the efficacy.Logistic regression analysis showed that A-Tg,Tg reduction index and AJCC staging were independent influencing factors for the efficacy of the first 131I therapy in patients with low-to-moderate risk DTC(P＜0.05).Conclusion Detection of A-Tg and Tg reduction index in pa-tients with low-to-moderate risk DTC can help predict the effect of postoperative first 131I therapy,and the combination of the two has better efficiency,and can provide guidance for future treatment arrangements.
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