The Expression of TEL-AML1 Fusion Gene in Children with Acute Lymphoblastic Leukemia and Its Influence on the Curative Effect and Prognosis
Objective To investigate the expression of TEL-AML1 fusion gene in children with acute lymphoblastic leu-kemia(AML)and its effect on its efficacy and prognosis.Methods 106 children with acute lymphoblastic leukemia were collect-ed and the TEL-AML1 gene expression was detected by nested PCR.According to the expression of TEL-AML1 gene,they were divided into TEL/AML1+group and TEL/AML1-group.Results There were statistically significant differences in age and fe-ver rate between the 2 groups(P＜0.05),but no statistically significant differences in other clinical characteristics between the 2 groups(P＞0.05).There was significant difference in clinical efficacy between TEL/AML1+group and TEL/AML1-group(x2=7.617,P=0.022).MRD level at week 12 May be a prognostic factor of TEL-AML1 fusion gene positive in children with a-cute lymphoblastic leukemia(P＜0.05).Conclusion The survival rate of children with TEL-AML1 fusion gene positive acute lymphoblastic leukemia is higher,and the level of MRD at week 12 may be a prognostic factor.
万方数据
维普
