Expression of TRPA1 and TRPV4 in Gingival Tumors and Their Correlation with Clini-copathological Characteristics
Objective To investigate the expression of transient receptor potential channel A1(TRPA1)and transient receptor potential channel V4(TRPV4)in gingival tumors and their correlation with clinicopathological characteristics.Methods 78 patients with gingival tumor were selected as the study subjects.All patients underwent surgical treatment.During the opera-tion,the gingival tumor tissue was removed and a small amount of normal gingival tissue was removed for examination.The expres-sion of TRPA1 and TRPV4 in the samples was determined by immunohistochemical SP method,and the expression of TRPA1 and TRPV4 in gingival tumor tissue and normal gingival tissue were compared;The relationship between the expression of TRPA1,TR-PV4 and clinical characteristics was analyzed;The relationship between the expression of TRPA1 and TRPV4 and the recurrence rate of patients was analyzed after 1 year follow-up.Results The positive expression rate of TRPA1 and TRPV4 in gingival tumor tissue was higher than that in normal tissue(P;The age of TRPA1 positive group was less than 50 years old,and the proportion of non-drug gingival hyperplasia was higher than that of negative group(P＜0.05);There was no significant difference in sex,BMI,course of disease and pathological classification between the two groups(P＞0.05);The age of TRPV4 expression group was less than 50 years old,and the proportion of non-drug gingival hyperplasia was higher than that of the negative group(P;There was no significant difference in sex,BMI,course of disease and pathological classification between the 2 groups(P＞0.05);78 patients were followed up for 1 year,30 patients recurred,the recurrence rate was 38.46％(30/78);The positive expression rates of TR-PA1 and TRPV4 in patients with recurrence were higher than those in patients without recurrence(P＜0.05).Conclusion TR-PA1 and TRPV4 are highly expressed in gingival tumors,and patients with high expression have a high risk of recurrence after surgery,which can guide clinical treatment to a certain extent.
Gingival tumorTransient receptor potential channelDrug-induced gingival hyperplasiaClinical features
万方数据
维普
