The Expression of JMJD2B and HPIP in Cervical Cancer Tissue and Their Relationship with Clinical Prognosis
Objective To analyze the expression of JMJD2B and transcription factor interacting protein(HPIP)in cervi-cal cancer tissue and its relationship with prognosis.Methods 75 patients with cervical cancer were selected,and their cancerous tissues and normal tissues adjacent to the tumor(≥3 cm from the edge of the tumor tissue)were collected into the observation group and the control group,respectively.The differences in the expression of JMJD2B and HPIP between the 2 groups were deter-mined by immunohistochemistry,and the general data such as the age of the patients were collected,and the relationship between the expression of JMJD2B and HPIP and the clinicopathological characteristics of the patients was analyzed;The relationship be-tween the expression of JMJD2B and HPIP and the prognosis of patients with cervical cancer was analyzed after another 1-year fol-low-up.Results The positive expression rates of JMJD2B and HPIP in the observation group were 53.33％(40/75)and 45.33％(34/75)respectively,which were higher than those in the control group(24.00％(18/75)and 20.00％(15/75),and the difference was statistically significant(P＜0.05);The positive expression of JMJD2B and HPIP was not related to the age,pathological type and tumor stage of cervical cancer patients,and the difference was not statistically significant(P＞0.05);The difference was statistically significant(P;The 1-year survival rate of JMJD2B and HPIP positive expression patients was 65.00％(26/40)and 55.88％(19/34)respectively,which were lower than 85.71％(30/35)and 90.24％(37/41)of the negative ex-pression patients,and the difference was statistically significant(P＜0.05).Conclusion JMJD2B and HPIP are highly ex-pressed in the cancer tissue of cervical cancer patients,and are related to the tumor diameter,differentiation degree,lymph node metastasis,and infiltration degree of the patients.The higher the positive expression rate of both,the lower the survival rate of pa-tients.
Cervical cancerJMJD2BPre hematopoietic B cell leukemia transcription factor interacting proteinProgno-sis
万方数据
维普
