Expression Level of TPX2 in Cervical Cancer and Its Correlation with Radiotherapy Sensitivity
Objective To explore the expression level of TPX2 in cervical cancer and its correlation with radiotherapy sensitivity.Methods 54 cases of cervical cancer biopsy specimens were selected as the observation group,and 35 cases of nor-mal cervical tissue specimens were selected as the control group.The expression of TPX2 protein in the 2 groups of tissues was de-tected by immunohistochemistry,and the relationship between the expression level of TPX2 protein in cervical cancer tissues and patients'age,pathological type,clinical stage,pathological differentiation and lymph node metastasis was analyzed.54 patients with cervical cancer were treated with pelvic intensity-modulated radiotherapy.After treatment,they were divided into two groups ac-cording to the curative effect of radiotherapy.CR was highly sensitive group and PR and SD were low sensitive groups.The rela-tionship between the expression of TPX2 protein in cervical cancer tissues and radiotherapy sensitivity was analyzed.Results The positive expression rate of TPX2 protein in cervical cancer(87.04％)was significantly higher than that in normal cervical tissues(8.57％),and the difference was statistically significant(P＜0.05).The expression of TPX2 protein had nothing to do with the age and pathological type of cervical cancer patients(P＞0.05).It was related to clinical stage,differentiation degree and lymph node metastasis(P＜0.05).The expression intensity of TPX2 protein in low sensitivity group was significantly higher than that in high sensitivity group(P＜0.05).Conclusion TPX2 protein is highly expressed in cervical cancer,and its expression level is related to the clinical stage,differentiation degree and lymph node metastasis of cervical cancer.TPX2 level will affect the sensitivity of radiotherapy for cervical cancer,and its high expression will lead to tumor radiation resistance.The expression level of TPX2 is of great significance in predicting the curative effect of radiotherapy in patients with cervical cancer.
万方数据
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