Comparison of Clinical Effects between Ultrasound-Guided Radiofrequency Ablation and Total Laparoscopic Radical Thyroidectomy in Treating Papillary Thyroid Microcarcinoma
Objective To compare the clinical effects of ultrasound-guided radiofrequency ablation(RFA)and total lap-aroscopic radical thyroidectomy in treating papillary thyroid microcarcinoma(PTMC).Methods 60 PTMC patients were random-ly grouped into a laparoscopy group(30 cases)and an ablation group(30 cases).The endoscopy group was given total laparoscop-ic radical thyroidectomy,and the ablation group was given ultrasound-guided RFA.The operation-related indicators(hospitalization time,intraoperative blood loss,operation time and postoperative pain degree),thyroid hormone levels(free triiodothyronine(FT3),free thyroxine(FT4),thyroid stimulating hormone(TSH)],inflammatory factors[tumor necrosis factor alpha(TNF-α),C-reactive protein(CRP),interleukin-6(IL-6)]and complications were compared.Results The hospital stay,intraoperative blood loss,op-eration time and postoperative pain degree in the ablation group were obviously lower than those in the endoscopic group(P＜0.05);there was no obvious difference in serum FT3,FT4 and TSH levels in the ablation group before and after surgery(P＞0.05).Compared with before operation,the postoperative serum FT3 and FT4 levels in the endoscopic group were obviously lower(P＜0.05),and the endoscopic group were obviously lower than the ablation group(P＜0.05);the postoperative serum TSH lev-el in the endoscopic group was obviously increased(P＜0.05),and the endoscopic group was obviously higher than that in the ab-lation group(P＜0.05).Compared with before operation,postoperative serum TNF-α,IL-6,and CRP levels in both groups were obviously decreased(P＜0.05),but the ablation group were obviously lower than the endoscopic group(P＜0.05).There was no significant difference in the incidence of complications between the 2 groups(P＞0.05).Conclusion Compared with total lapa-roscopic radical thyroidectomy,ultrasound-guided RFA in the treatment of PTMC can more effectively reduce the inflammatory re-sponse,promote recovery,reduce intraoperative blood loss,preserve thyroid function,and be safe and effective with less trauma.
万方数据
维普
