Effect of High-dose Progesterone Combined with Hysteroscopic Resection on Pregnancy Rate in Young Patients with Early Endometrial Cancer
Objective To investigate the effect of high-dose progesterone combined with hysteroscopic resection on the pregnancy rate of young patients with early endometrial cancer.Methods 68 young patients with early EC were selected as the research object.They were randomly divided into the control group(n=34)and the observation group(n=34)according to the method of random number table.The patients in both groups underwent hysteroscopic resection.After operation,the control group was given megestrol acetate tablets 160 mg/time,and the observation group was given megestrol acetate tablets 480 mg/time.6 months later,the clinical efficacy,serum levels of sex hormones[estradiol(E2),luteinizing hormone(LH)],tumor markers[car-bohydrate antigen 125(CA125),human epididymal secretory protein 4(HE4)]and adverse reactions of the two groups were com-pared.The pregnancy rate and pregnancy outcome of the 2 groups were statistically compared after a 1-year follow-up.Results The ORR in the observation group(94.12％)was higher than that in the control group(85.29％)(P＜0.05).Compared with that before treatment,the levels of serum E2,LH,CA125 and HE4 in the control group and the observation group decreased after treatment(P＜0.05).After treatment,the levels of serum E2,LH in the observation group were higher and the levels of serum CA125 and HE4 were lower than those in the control group(P＜0.05).During 1 year follow-up,the pregnancy rate of 79.41％and the term delivery rate of 64.71％in the observation group were significantly higher than those of 52.94％and 35.29％in the control group(P＜0.05).The adverse reaction rate of 5.88％in the observation group was significantly lower than that of 23.53％in the control group(P＜0.05).Conclusion High-dose megestrol acetate combined with hysteroscopic resection is of positive significance for the early treatment of young patients with EC.It can increase the pregnancy rate of patients,improve the fertility function,and has less adverse reactions.It has clinical promotion value.
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维普
