Risk Prediction of Secondary Intracranial Infection of Acinetobacter Baumannii in Glioma Patients After Surgery
Objective To explore the risk factors of secondary intracranial infection of Acinetobacter baumannii in pa-tients with glioma after surgery and build a prediction modell.Methods The clinical data of 90 patients with intracranial infec-tion after surgery for glioma were collected.According to the test results,the patients enrolled were divided into Acinetobacter bau-mannii infection group(n=32)and non-Acinetobacter baumannii infection group(n=58).To analyze the risk factors of intracra-nial infection of Acinetobacter baumannii in glioma patients after surgery,use multiple Logistic regression analysis to screen the independent risk factors and establish a prediction model,draw the working characteristics(ROC)curve of subjects to test the ef-fectiveness of the prediction model.Results There were statistically significant differences between the 2 groups in terms of post-operative cerebrospinal fluid leakage,preoperative preventive use of antibiotics,perioperative hormone use,preoperative GCS score,and hypoproteinemia(P＜0.05).Multivariate logistic regression analysis found that postoperative cerebrospinal fluid leak-age,preoperative GCS score＜8,and hypoproteinemia were independent risk factors for intracranial infection induced by Acineto-bacter baumannii in glioma patients after surgery(P＜0.05).A prediction model was constructed based on these risk factors,and the area under the curve(AUC),Youden index,sensitivity and specificity of this prediction model were 0.807(95％CI:0.666～0.908,P＜0.001),0.460,75.00％,and 70.97％.Conclusion Postoperative cerebrospinal fluid leakage and hypoproteinemia are important factors influencing the occurrence of intracranial infection induced by Acinetobacter baumannii in glioma patients af-ter surgery.The prediction model constructed based on these factors is of value in risk of assessment of intracranial infection in-duced by Acinetobacter baumannii in glioma patients after surgery.
Acinetobacter baumanniiIntracranial infectionGliomaRisk factorPrediction model
万方数据
维普
