Hp Infection and Expressions of Survivin and MMP-2 in Gastric Cancer and Their Correlation
Objective To study Helicobacter pylori(Hp)infection and expressions of survivin and matrix metalloprotei-nase-2(MMP-2)in gastric cancer,and their correlation.Methods 120 patients with gastric cancer were selected as the research subjects.The expressions of survivin and MMP-2 in cancer tissues and adjacent tissues were detected by immunohistochemical staining,and their relationship with clinicopathological characteristics was analyzed.Hp infection was detected.The pathological characteristics and expressions of survivin and MMP-2 in gastric cancer patients with different infection status were compared.The relationship between Hp infection and expressions of survivin and MMP-2 was analyzed by Spearman method.Results The posi-tive expression rates of survivin and MMP-2 in gastric cancer tissues were 76.67％and 73.33％,significantly higher than those in adjacent tissues(16.67％and 13.33％)(P＜0.05).The expressions of survivin and MMP-2 were related to TNM staging,tumor differentiation degree,tumor invasion depth and lymph node metastasis(P＜0.05),but not related to age,gender or tumor diameter(P＞0.05).There were 65 Hp positive cases and 55 negative cases.The incidence of low-moderate differentiation,tumor invasion depth and incidence of lymph node metastasis in Hp-positive group were higher than those in Hp-negative group(P＜0.05).There was no significant difference between the two groups in age,gender,TNM staging,or tumor diameter(P＞0.05).The positive expression rates of survivin and MMP-2 in Hp-positive group were 87.69％and 83.08％,significantly higher than those in Hp-negative group(63.64％and 61.82％)(P＜0.05).Spearman correlation analysis found that Hp infection was posi-tively correlated with expressions of survivin and MMP-2(γ=0.357,0.349,P＜0.05).Conclusion The expressions of survivin and MMP-2 are related to the occurrence of gastric cancer.Hp infection can increase the expressions of survivin and MMP-2 in gastric cancer tissues.
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