Analysis of the Prognostic Value of FasL and Caspase-9 Expression Levels in Patients with Hepatocellular Carcinoma After Interventional Therapy
Objective To investigate the changes and significance of FasL and Caspase-9 expression in patients with hepatocellular carcinoma(HCC)before and after interventional therapy.Methods A total of 68 patients with HCC who received interventional treatment were selected as the study subjects.The levels of FasL and Caspase-9 in HCC patients before and after treatment were compared.The recurrence rate of HCC patients was statistically analyzed and divided into recurrent group and non recurrent group.The clinical data,levels of FasL and Caspase-9 before and after treatment were compared between the recurrent group and the non recurrent group.Logistic multivariate regression analysis was used to analyze the risk factors for after treatment recurrence in patients with HCC.Subjects'working characteristic curve(ROC)was prepared to evaluate the predictive value of FasL and Caspase-9 for after treatment recurrence in HCC patients using area under curve(AUC).Results Compared with pre treatment,the level of FasL in patients after treatment decreased(P＜0.05),while the level of Caspase-9 increased(P＜0.05).By the end of follow-up,the recurrence rate of HCC patients undergoing interventional therapy was 47.06％(32/68).The maxi-mum tumor diameter,number of tumors,and FasL level after treatment in the recurrent group were higher than those in the non re-current group(P＜0.05),while the Caspase-9 level after treatment was lower than that in the non recurrent group(P＜0.05).Multivariate analysis showed that the maximum tumor diameter(OR=2.619,95％CI:1.126～6.092),FasL after treatment(OR=2.134,95％CI:1.264～3.602),and Caspase-9 after treatment(OR=0.975,95％CI:0.954～9.997)were related factors af-fecting after treatment recurrence in HCC patients(P＜0.05).ROC analysis showed that the sensitivity of FasL,Caspase-9 and their combined detection to predict the recurrence of HCC patients after treatment were 78.12％(95％CI:59.56％～90.06％),71.87％(95％CI:53.02％～85.60％),93.75％(95％CI:77.78％～98.91％),the specificity were 72.22％(95％CI:54.57％～85.21％),80.56％(95％CI:63.43％～91.20％),72.22％(95％CI:54.57％～85.21％),and the AUC were 0.794(95％CI:0.679～0.883),0.785(95％CI:0.668～0.875),0.867(95％CI:0.763～0.937).Conclusion After treat-ment,the level of FasL decreases and the level of Caspase-9 increases in HCC patients.After treatment,FasL and Caspase-9 can be used as important reference indicators for clinical evaluation of recurrence after treatment in HCC patients.
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