The Relationship Between the Expression of Serum PCNA and IGF-1 and the Prognosis of Lung Cancer Patients
Objective To investigate the relationship between the expression of serum PCNA and IGF-1 and the progno-sis of patients with lung cancer.Methods A retrospective analysis was conducted on the clinical data of 80 lung cancer patients and 80 lung benign lesions patients.80 lung cancer patients were included in the observation group,and 80 lung benign lesions patients were included in the control group.According to the World Health Organization(WHO)Solid Tumor Efficacy Evaluation Criteria(RECIST),patients underwent surgery were divided into a good prognosis group(n=65)and a poor prognosis group(n=15),and their serum proliferating cell nuclear antigen(PCNA)and the levels of insulin-like growth factor-1(IGF-1)were detec-ted and comparatively analyzed.Analyze the diagnostic efficacy of serum PCNA and IGF-1 levels in predicting the prognosis of lung cancer,as well as their correlation with poor prognosis.Results The positive rates of serum PCNA and IGF-1 expression in the observation group were significantly higher than those in the control group(P＜0.05);The expression levels of serum PCNA and IGF-1 in the observation group were significantly higher than those in the control group(P＜0.05).Compared with the good prognosis group,the expression levels of serum PCNA and IGF-1 in the poor prognosis group were significantly higher(P＜0.05).Compared with single serum PCNA and IGF-1 detection,the sensitivity and specificity of serum PCNA+IGF-1 combined detection in the prognosis prediction of lung cancer were significantly higher(P＜0.05).Serum PCNA and IGF-1 were negatively correlated with the prognosis of patients with lung cancer(P＜0.05).Conclusion Serum PCNA and IGF-1 are correlated with the prognosis of lung cancer,and the prognosis of lung cancer can be predicted by detecting their expression levels.
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