Expression of bFGF,Ki-67 and ADAM15 in Breast Cancer and Their Correlation with Clinicopathological Characteristics
Objective To investigate the expression of basic fibroblast growth factor(bFGF),Ki-67 and disintegrin met-alloproteinase 15(AD AM 15)in breast cancer tissues and their relationship with clinicopathological characteristics.Methods 87 patients with breast cancer were selected as the research object,and all of them were treated by surgery.Tumor specimens and tumor adjacent markers were collected for immunohistochemical staining.The expression of bFGF,Ki-67 and ADAM 15 in tumor tissue and adjacent tissue were compared,and the relationship between the expression of bFGF,Ki-67 and ADAM 15 and clinical pathological characteristics was analyzed.Results The positive rates of bFGF,Ki-67,and ADAM 15 in tumor tissues were higher than those in adjacent tissues,with statistical significance(P＜0.05);The proportion of tumor stages Ⅲ～Ⅳ,lymph node metas-tasis,and tumor diameter ≥3 cm in the bFGF positive group was higher than that in the bFGF negative group,and the difference was statistically significant(P＜0.05);The proportion of Ki-67 positive group with stage Ⅲ～Ⅳ tumors,lymph node metastasis,and tumor diameter≥3 cm was higher than that of Ki-67 negative group,and the difference was statistically significant(P＜0.05);The proportion of tumors in stages Ⅲ～Ⅳ,lymph node metastasis,and tumor diameter ≥3 cm in the ADAM 15 positive group was higher than that in the ADAM 15 negative group,and the difference was statistically significant(P＜0.05).Conclusion bFGF,Ki-67 and ADAM 15 have high positive expression in breast cancer tissue,which is closely related to tumor stage,lymph node metastasis and tumor diameter,and may be a new target to improve the treatment of breast cancer.
Breast cancerBasic fibroblast growth factorImmunohistochemistryClinical expressionPathological char-acteristics
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