The Relationship Between Serum GPAA1 and OPN Expression and Prognosis of Acute Myeloid Eukemia
Objective To explore the relationship between the expression of serum glycosylphosphatidylinositol anchored adsorption protein 1(GPAA1)and osteopontin(OPN)and the prognosis of acute myeloid leukemia(AML).Methods Clinical data of 60 AML patients(observation group)and 60 healthy volunteers(control group)were retrospectively analyzed.Patients in the observation group were divided into a good prognosis group(46 cases)and a poor prognosis group(14 cases)based on their prognosis.Serum GPAA1 and OPN levels were measured in both groups,and the diagnostic efficacy and correlation of serum GPAA1 and OPN levels in AML prognosis detection were analyzed.Results Compared with the control group,the expression lev-els of serum GPAA1 and OPN in the observation group were significantly higher(P＜0.05);Compared with the group with good prognosis,the expression levels of serum GPAA1 and OPN in the group with poor prognosis were significantly higher(P＜0.05);The diagnostic sensitivity and specificity of GPAA1+OPN combined detection for AML prognosis are significantly higher than those of GPAA1 and OPN alone detection(P＜0.05);There was a negative correlation between serum GPAA1,OPN and the prognosis of AML(P＜0.05).Conclusion There is a certain correlation between serum GPAA1 and OPN and the prognosis of AML.Based on the changes in their expression levels,the prognosis of patients can be effectively judged,and they can be used as predictive indicators for patient prognosis.
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