Relationship Between Serum 25-hydroxyvitamin D,Carbohydrate Antigen 125 and Clinicopathologic Parameters in Patients with Uterine Fibroids
Objective To investigate the relationship between serum 25-hydroxyvitamin D[25-(OH)D]and Carbohy-drate antigen 125(CA125)and clinicopathologic parameters in patients with uterine fibroids.Methods 82 patients with hystero-myoma were selected retrospectively as hysteromyoma group,and 80 healthy women were selected as the control group.The levels of serum 25-(OH)D and CA125 were compared between the 2 groups.The relationship between preoperative serum 25-(OH)D and CA125 and clinicopathologic parameters in patients with uterine fibroids was observed,and the correlation between 25-(OH)D and CA125 and clinicopathologic parameters was analyzed by multivariate Logistic regression analysis.Pearson correlation coef-ficient was used to analyze the correlation between serum 25-(OH)D and CA125 levels in patients with uterine fibroids.Results Compared with the control group,the serum 25-(OH)D level was decreased and the serum CA125 level was increased in the u-terine fibroids group before surgery(P＜0.05).Compared with the preoperative level,the serum 25-(OH)D level was increased and the serum CA125 level was decreased in the uterine fibroids group after surgery(P＜0.05).Preoperative serum 25-(OH)D and CA125 levels were significantly correlated with the diameter,location,type,volume and number of hysteromyoma(P＜0.05).Multiple Logistic regression analysis showed that the diameter,location,type,volume and number of fibroids were negatively corre-lated with preoperative serum 25-(OH)D level and positively correlated with serum CA125 level(P＜0.05).Pearson correlation analysis showed that preoperative serum 25-(OH)D and CA125 levels in patients with uterine fibroids were negatively correlated(P＜0.05).Conclusion Serum 25-(OH)D and CA125 levels in patients with uterine fibroids are closely related to clinicopath-ological parameters,and play an important role in the occurrence and development of the disease.
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