Correlation Between Human Papilloma Virus 16/18 Infection and CyclinD1,P53 Protein in Bladder Cancer Tissues
Objective To analyze the correlation between human papilloma virus(HPV)16/18 infection and cyclin D1(cyclinD1),P53 protein in bladder cancer tissues.Methods The cancer tissues and para-cancerous tissues from 62 patients with bladder cancer were collected.The expression levels of HPV16/18,cyclinD1 and P53 protein in bladder cancer tissues and para-cancerous tissues were detected by immunohistochemical staining and semi-quantitative scoring method.The relationship be-tween their expressions and clinicopathological characteristics of bladder cancer,and the correlation between THPV16/18 and cy-clinD1,p53 protein were analyzed.Results The positive rates of HPV16/18,cyclinD1 and P53 protein in bladder cancer tissues were higher than those in para-cancerous tissues(P＜0.05).In bladder cancer tissues,positive rates of HPV16/18,cyclinD1 and P53 protein in patients with high pathological grading,high clinical staging and distant metastasis were higher than those with low pathological grading,low clinical staging and distant non-metastasis(P＜0.05).The positive rate of cyclinD1 and P53 protein in HPV16/18 positive group were higher than those in HPV16/18 negative group(P＜0.05).In bladder cancer tissues,HPV16/18 was not correlated with cyclinD1(P＞0.05),while positively correlated with P53 protein(P＜0.05).Conclusion HPV 16/18,cyclinD1 and P53 protein are all involved in the occurrence and development of bladder cancer.HPV 16/18 can affect the expres-sion of P53 protein and participate in the progression of bladder cancer.
Human papilloma virusBladder cancerCyclin D1P53 protein
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