Expression of PCNP and TGF-β 1in Adenoid Cystic Carcinoma of the Salivary Gland and Analysis of its Correlation with Clinicopathological Characteristics
Objective To explore the expression of PCNP and TGF-β1 in salivary adenoid cystic carcinoma(SACC)tis-sues and its relationship with clinical pathological characteristics.Methods 58 SACC patients were selected,and all patients un-derwent surgical treatment.During the surgery,cancer tissue and adjacent normal tissue were collected for examination.Immuno-histochemical SP staining was used to detect positive expression of PCNP and TGF-β1 in both tissues.The relationship between expression of PCNP and TGF-β1 and patients'age,gender,body mass index,tumor location,lymph node metastasis,tumor size,and nerve invasion were analyzed.Results The positive expression rate of PCNP and TGF-β1 in cancer tissues was higher in the control group,and the difference was statistically significant(P＜0.05);PCNP positive,TGF-β 1 positive patients with tumor size≥3 cm,and nerve invasion had higher proportion than PCNP negative and TGF-β1 negative patients,the difference is statistically significant(P＜0.05);Age,gender,body mass index,tumor location,lymph node metastasis status of PCNP and TGF-β1 positive patients and PCNP and TGF-β1 negative patients,the difference was not statistically significant(P＞0.05).Conclusion PCNP and TGF-β1 is highly expressed in SACC tissue,and closely related to tumor size and neural invasion,and may provide new direc-tions for clinical treatment.
Adenoid cystic carcinoma of the salivary glandTransforming growth factor β 1Nuclear protein PCNPClinical expressionPathological characteristics
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