Time-Signal Intensity Curve in Dynamic Contrast-Enhanced MRI in Relation to Molecular Subtyping of Breast Cancer
Objective To discuss the correlation between time-intensity curves(TIC)in dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI)and molecular typing in breast cancer patients.Methods 110 breast cancer patients were enrolled,and classified into Luminal A subtype,Luminal B subtype,HER2-positive subtype and triple-negative subtype ac-cording to the response to the expression status of estrogen receptor,progesterone receptor,and human epidermal growth factor re-ceptor 2.DCE-MRI was performed on patients of four subtypes.The histogram parameters volume transfer constant(Ktrans),rate constant(Kep)and TIC were compared among different subtypes.Results Among the 110 patients,30.00％(33/110)were Lu-minal A,27.27％(30/110)were Luminal B,30.90％(34/110)were HER-2 positive,and 11.81％(13/110)were triple nega-tive.The Ktrans and Kepvalues were not statistically significant between Luminal A and Luminal B subtypes,and the Ktrans and Kep values either yielded no statistical difference between HER-2-positive and triple-negative subtypes(all P＞0.05),while the Ktrans and Kep values of Luminal A and Luminal B subtypes were lower than those of HER-2-positive and triple-negative types(P＜0.05).Within Luminal A type,TIC was inflow type in 5 cases,platform type in 20 cases and outflow type in 8 cases.Within Lu-minal B type,TIC was inflow type in 2 cases,platform type in 10 cases and outflow type in 18 cases.Within HER2-positive type,TIC was inflow type in 4 cases,platform type in 11 cases and outflow type in 19 cases.Within triple-negative type,TIC was inflow type in 4 cases,platform type in 3 cases and outflow type in 6 cases.The TIC in DCE-MRI demonstrated statistical difference a-mong patients of different subtypes(P＜0.05).Conclusion The hemodynamic parameters derived from DCE-MRI of different molecular profiles are different,and clinicians can make preliminary prediction of molecular staging of breast cancer through TIC in DCE-MRI.
Breast cancerDynamic contrast-enhanced MRITime-intensity curveMolecular typing
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