Objective To retrospectively analyze the prognostic factors of patients with esophageal cancer perforation.Methods 138 cases of esophageal cancer were collected and diagnosed with esophageal cancer perforation through relevant ima-ging examinations,esophagoscopy,or postoperative pathological examination.Kaplan Meier survival analysis was used to assess prognostic factors,and propensity score matching analysis was used to assess the impact of subsequent treatments(radiotherapy,chemotherapy,surgery),stent implantation,and/or nutritional support on patient survival.Results The median overall survival of all patients was 6 months.Univariate analysis showed that gender,radiotherapy,enteral nutrition support,and the presence or ab-sence of deep ulcer before treatment were related to the overall survival(P＜0.05).Multivariate analysis showed that the survival of women was better than that of men,and enteral nutrition support treatment could improve the survival.Other factors have no sig-nificant impact on survival.Matching analysis showed that subsequent treatment,radiotherapy,parenteral and parenteral nutrition,parenteral nutrition alone,and stent implantation did not affect survival of patients.Only parenteral nutrition alone achieved surviv-al benefits(P＜0.05).Conclusion For the cancerous perforation of esophageal cancer,the median survival is short,and the subsequent treatment(radiotherapy,chemotherapy,surgery,etc.)for the primary focus of perforation can not prolong the survival of patients.Stent implantation also cannot improve survival.Enteral nutrition is essential for these patients.
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