摘要
目的 探讨经尿道钬激光膀胱肿瘤切除术(HoLRBT)治疗表浅层膀胱癌的临床效果及安全性.方法 选取70例表浅层膀胱癌患者,按随机数字表法分为2组,各35例.对照组行经尿道膀胱肿瘤电切术(TURBT)治疗,观察组行HoLRBT治疗.比较2组手术情况、血清相关指标、炎症因子水平及并发症.结果 观察组膀胱冲洗、尿管留置及住院时间分别为(19.58±2.14)min、(20.34±3.35)d、(8.96±1.15)d,均短于对照组的(32.54±3.49)min、(35.41±4.12)d、(13.75±2.14)d;术中出血量为(26.58±2.35)ml,少于对照组的(40.18±4.27)ml,差异有统计学意义(P＜0.05).观察组术后恶性肿瘤特异生长因子(TSGF)、肝细胞生长因子(HGF)水平分别为(65.36±6.15)U/ml、(2.21±0.32)µmol/L,低于对照组的(80.41±8.36)U/ml、(3.42±0.45)µmol/L,有统计学差异(P＜0.05);观察组术后白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)及 C 反应蛋白(CRP)水平分别为(57.25±5.19)pg/ml、(39.39±4.28)pg/ml、(12.25±2.19)mg/L,低于对照组的(64.31±6.28)pg/ml、(45.41±4.38)pg/ml、(15.41±2.23)mg/L,有统计学差异(P＜0.05).观察组并发症较对照组少,有统计学差异(P＜0.05).结论 HoLRBT治疗表浅层膀胱癌效果更佳,可缩短膀胱冲洗、尿管留置时间,减轻手术创伤,降低TSGF、HGF水平,且并发症少.
Abstract
Objective To investigate the clinical efficacy and safety of transurethral holmium laser resection of bladder tumors(HoLRBT)for superficial bladder cancer.Methods 70 cases of superficial bladder cancer were randomly divided into 2 groups,35 cases in each group.The control group received transurethral resection of bladder tumors(TURBT)treatment,while the observation group received HoLRBT treatment.Compare the surgical conditions,serum related indicators,levels of inflammatory factors,and complications between the 2 groups.Results The bladder irrigation,indwelling catheter,and hospitalization time in the observation group were(19.58±2.14)minutes,(20.34±3.35)days,and(8.96±1.15)days,which were shorter than those in the control group(32.54±3.49)minutes,(35.41±4.12)days,and(13.75±2.14)days;The intraoperative bleeding volume was(26.58±2.35)ml,which was lower than the control group's(40.18±4.27)ml,and the difference was statistically significant(P＜0.05).The postoperative levels of malignant tumor specific growth factor(TSGF)and hepatocyte growth factor(HGF)in the observation group were(65.36±6.15)U/ml and(2.21±0.32)µMol/L,respectively,lower than the control group's(80.41±8.36)U/ml,(3.42±0.45)µMol/L,with statistical difference(P＜0.05);Postoperative interleukin-6(IL-6)and tumor necrosis factor in the observation group-α(TNF)-α)The levels of C-reactive protein(CRP)were(57.25±5.19)pg/ml,(39.39±4.28)pg/ml,and(12.25±2.19)mg/L,which were lower than the control group's(64.31±6.28)pg/ml,(45.41±4.38)pg/ml,and(15.41±2.23)mg/L,with statistical differences(P＜0.05).The observation group had fewer complications compared to the control group,with a statistical difference(P＜0.05).Conclusion HoLRBT is more effective in the treatment of superficial bladder cancer,which can shorten the time of bladder flushing and catheter indwelling,reduce the surgical trauma,reduce the lev-els of TSGF and HGF,and have fewer complications.
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