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原发鼻腔早期非霍奇金淋巴瘤患者预后的相关影响因素分析

Analysis of Prognostic Factors Related to Early Non Hodgkin's Lymphoma in Primary Nasal Cavity Patients

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目的 分析原发鼻腔早期非霍奇金淋巴瘤(NHL)患者预后的相关影响因素.方法 选取105例原发鼻腔早期NHL患者,对患者随访2年,根据患者的生存情况分为预后不良组(病死)与预后良好组(存活),比较两组资料,通过Cox回归分析原发鼻腔早期NHL患者预后的相关影响因素.结果 随访2年统计预后情况,105例原发鼻腔早期NHL患者中,有22例死亡,死亡率为20.95%(22/105),83例生存,生存率为79.05%(83/105).经KM法绘制生存曲线显示,22例死亡患者平均生存时间为(12.32±4.48)个月;预后不良组患者临床分期和血清中性粒细胞与淋巴细胞比值(NLR)、白细胞介素6(IL-6)、C反应蛋白(CRP)水平高于预后良好组,差异有统计学意义(P<0.05);经Cox回归分析结果显示,临床分期Ⅱ期、NLR水平高、IL-6水平、CRP水平高均与原发鼻腔早期NHL患者预后不良有关(P<0.05).结论 原发鼻腔早期NHL患者预后情况不理想,与临床分期和血清NLR、IL-6、CRP水平高有关.
Objective To analyze the prognostic factors related to early non Hodgkin's lymphoma(NHL)patients in the primary nasal cavity.Methods 105 patients with early primary nasal NHL were selected and followed up for 2 years.The pa-tients were divided into the poor prognosis group(mortality)and the good prognosis group(survival)based on their survival sta-tus.The data of the 2 groups were compared and Cox regression analysis was used to analyze the relevant factors affecting the prognosis of early primary nasal NHL patients.Results After a 2-year follow-up,the prognosis was statistically analyzed.Among 105 patients with early primary nasal NHL,22 died with a mortality rate of 20.95%(22/105),and 83 survived with a survival rate of 79.05%(83/105).The survival curve drawn by KM method showed that the average survival time of 22 patients who died was(12.32±4.48)months;The clinical stage,serum neutrophil to lymphocyte ratio(NLR),interleukin-6(IL-6),and C-reactive protein(CRP)levels in patients with poor prognosis were higher than those in patients with good prognosis,with statistically sig-nificant differences(P<0.05);The results of Cox regression analysis showed that clinical stage Ⅱ,high NLR levels,IL-6 levels,and CRP levels were all associated with poor prognosis in patients with early primary nasal NHL(P<0.05).Conclusion The prognosis of early primary nasal NHL patients is not ideal,which is related to clinical staging and high levels of serum NLR,IL-6,and CRP.

Non Hodgkin's lymphomaCavidade nasal PrognosisInfluence factor

李雪姣、楚楚、李蓓、黄菊芳、胡佩瑞

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450000 郑州大学第一附属医院

非霍奇金淋巴瘤 鼻腔 预后 影响因素

2024

实用癌症杂志
江西省肿瘤医院 江西省肿瘤研究所

实用癌症杂志

影响因子:1.241
ISSN:1001-5930
年,卷(期):2024.39(7)