摘要
目的 分析糖类抗原125(CA125)、糖类抗原199(CA199)、细胞角蛋白19片段(CYFRA-21)、癌胚抗原(CEA)对非小细胞肺癌(NSCLC)患者脑转移的诊断价值.方法 选取NSCLC患者共96例,根据其是否存在脑转移将其划分为转移组(32例)及未转移组(64例);另将行体检的75例健康体检者纳入健康组.抽取全部研究对象的晨起空腹静脉血,检测血清CA125、CA199、CYFRA-21及CEA水平.绘制受试者工作曲线(ROC),分析CA125、CA199、CYFRA-21、CEA联合检测对NSCLC患者脑转移的诊断价值.结果 转移组的CA125、CA199、CYFRA-21、CEA水平高于未转移组、健康组,且未转移组的CA125、CA199、CYFRA-21、CEA水平高于健康组,差异有统计学意义(P＜0.05).ROC结果显示,CA125、CA199、CYFRA-21、CEA联合检测诊断NSCLC患者脑转移的曲线下面积(AUC)高于CA125、CA199、CYFRA-21、CEA单独诊断.结论 CA125、CA199、CYFRA-21、CEA在出现脑转移的NSCLC患者血清中的表达较高,四者联合检测能够有效诊断出患者是否存在脑转移,具有一定的诊断价值.
Abstract
Objective To analyze the diagnostic value of carbohydrate antigen 125(CA125),carbohydrate antigen 199(CA199),cytokeratin 19 fragment(CYFRA-21),and carcinoembryonic antigen(CEA)for brain metastasis in non-small cell lung cancer(NSCLC)patients.Methods A total of 96 NSCLC patients were selected and divided into a metastatic group(32 cases)and a non metastatic group(64 cases)based on the presence of brain metastasis;75 healthy examinees who underwent physical examinations were included in the health group,and fasting venous blood from all study subjects was extracted in the morning,and serum CA125,CA199,CYFRA-21,and CEA levels were detected.Receiver operating curve(ROC)was plotted to analyze the di-agnostic value of combined detection of CA125,CA199,CYFRA-21,and CEA for brain metastasis in NSCLC patients.Results The levels of CA125,CA1 99,CYFRA-21,and CEA in the transfer group were higher than those in the non transfer group and the healthy group,and the levels of CA125,CA199,CYFRA-21,and CEA in the non transfer group were higher than those in the healthy group,with statistical significance(P＜0.05);The ROC results showed that the area under the curve(AUC)for the com-bined detection of CA125,CA199,CYFRA-21,and CEA in diagnosing brain metastases in NSCLC patients was higher than that of CA125,CA199,CYFRA-21,and CEA alone.Conclusion CA125,CA199,CYFRA-21,and CEA are highly expressed in NSCLC patients with brain metastases.The combination of the four can effectively diagnose the presence of brain metastases in patients and has certain diagnostic value.
维普
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