Impacts of Inhaling Different Concentrations of Sevoflurane Combined with Remifentanil Anesthesia on Postoperative Anesthesia Recovery and Cognitive Function in Elderly Patients with Colorectal Cancer
Objective To explore the anesthesia effect of different concentrations of sevoflurane and remifentanil on eld-erly colorectal cancer patients,and its impacts on anesthesia recovery and cognitive function.Methods 110 elderly colorectal cancer patients were randomly grouped into group A and group B,with 55 patients in each group.Group A was anesthetized with 0.4MAC sevoflurane combined with remifentanil,while group B was anesthetized with 0.6MAC sevoflurane combined with remifentanil.The hemodynamic indicators,recovery status,MMSE scores,and serum factor levels were compared between the 2 groups.Results The heart rate(HR)and mean arterial pressure(MAP)of both groups first increased and then decreased,and at 5 minutes after anesthesia(T1),the levels of HR and MAP in group A decreased obviously compared to group B(P＜0.05);the time of recovery,recovery time of spontaneous breathing,and recovery time of directional ability in group A were obviously shorter than those in group B(P＜0.05);the MMSE score of the 2 groups showed a trend of first decreasing and then increasing,and the MMSE score of group A was obviously higher than that of group B at 1 and 12 hours after surgery(P＜0.05);the levels of tumor necrosis factor-α(TNF-α)and interleukin-1 β(IL-1 β)in group A were obviously lower than those in group B(P＜0.05).Conclusion Low concentration sevoflurane combined with remifentanil anesthesia is ideal for elderly patients undergoing colorectal cancer surgery,with minimal impact on cognitive function and high clinical application value.
Colorectal cancerSevofluraneRemifentanilAnesthesia recoveryCognitive function
万方数据
维普
