Analysis of Factors Leading to Difficult Healing of Perineal Incision After Miles Surgery for Rectal Cancer After Neoadjuvant Radiotherapy
Objective To explore the related factors that affect the difficulty of healing the perineal surgical incision af-ter neoadjuvant radiotherapy combined with radical resection of rectal cancer(Miles surgery).Methods A retrospective analysis was conducted on the clinical data of 125 patients with rectal cancer underwent Miles surgery after neoadjuvant radiotherapy.The healing status of postoperative perineal surgical incisions was statistically analyzed,and the relevant factors affecting the difficulty of postoperative perineal surgical incisions were analyzed through single factor and multiple factor analysis.Results Among the 125 patients who underwent Miles surgery for rectal cancer after neoadjuvant radiotherapy,34 patients had a difficult to heal peri-neal surgical incision,with a difficult to heal rate of 27.20％(34/125);Univariate analysis showed that gender,age,presence or absence of concomitant hypertension,body mass index,abdominal wall incision diameter,pelvic floor peritoneal repair,preopera-tive albumin were not associated with postoperative difficulty in healing of perineal surgical incisions in patients(P＞0.05);The presence or absence of diabetes,the interval between operations after radiotherapy,and the complete drainage of fluid in the in-jured mouth were related to the difficulty of perineal incision healing(P＜0.05);Logistic regression analysis showed that the com-plications of diabetes,the operation interval of 1 week after radiotherapy,and the incomplete drainage of the fluid in the injured mouth were the important factors for the difficulty in healing the perineal incision after surgery(P＜0.05).Conclusion The presence or absence of diabetes,the interval between operations after radiotherapy,and whether the fluid accumulated in the in-jured mouth is completely drained are related factors that affect the perineal incision healing after Miles operation for rectal cancer after neoadjuvant radiotherapy.Clinical attention should be paid to these factors,and relevant measures should be taken to promote the perineal incision healing after Miles operation.
Rectal cancerNeoadjuvant radiotherapyAbdominal perineal combined radical resection of rectal cancerIncision difficult to healInfluence factor
万方数据
维普
