The Expression of Serum IL-10 and CD4 in Cervical Cancer Patients and Their Relationship with HPV Typing
Objective To explore the expression of serum interleukin-10(IL-10)and cluster of differentiation 4(CD4)in cervical cancer patients,and analyze their relationship with human papilloma virus(HPV)typing.Methods Clinical medical records of 80 cervical cancer patients were collected and assigned to the cervical cancer group.In addition,data of 80 cervical pre-cancerous lesions patients and 80 healthy women who underwent physical examinations during the same period were collected and assigned to the precancerous lesions group and healthy control group,respectively.By comparing the expression of serum IL-10 and CD4 in the three groups of patients,the expression of serum IL-10 and CD4 in different pathological types of cervical cancer patients,the HPV typing in precancerous lesions group and cervical cancer group,and the expression of serum IL-10 and CD4 in different HPV typing,the expression of serum IL-10 and CD4 in cervical cancer patients and the relationship with HPV typing were discussed.Results Compared with the levels of IL-10 in three groups,cervical cancer grouP＞precancerous lesion grouP＞healthy control group(P＜0.05).Compared with the CD4 levels among three groups,the cervical cancer grouP＜precancerous le-sion grouP＜healthy control group(P＜0.05).The serum IL-10 levels in stage Ⅲ～Ⅳ patients were higher than those in stageⅠ～Ⅱ patients,and the CD4 levels were lower than those in stage Ⅰ～Ⅱ patients(P＜0.05).The serum IL-10 levels in pa-tients with lymph node metastasis were higher than those without lymph node metastasis,and the CD4 levels were lower than those without lymph node metastasis(P＜0.05).The proportion of high-risk HPV infection in the cervical cancer group was significant-ly higher than that in the precancerous lesion group(P＜0.05).According to the chi square test Phi coefficient analysis,there was a correlation between high-risk HPV subtypes and the occurrence of cervical cancer(Phi=0.016,P=0.032).The serum IL-10 level of high-risk type was higher than that of low-risk type,and the CD4 level was lower than that of low-risk type(P＜0.05).Conclusion There is a close relationship between serum IL-10 and CD4 levels and the occurrence and HPV subtypes of cervical cancer.The higher the IL-10 level and the lower the CD4 level,the greater the risk of high-risk HPV infection in patients,which can increase the risk of cervical cancer.
Cervical cancerInterleukin-10Cluster of differentiationHuman papilloma virus
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NSTL
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