HHLA2、FOXO3A在非小细胞肺癌组织中的表达及与其临床病理特征和预后的相关性
The Expression of HHLA2 and FOXO3A in NSCLC Tissues and Their Correlation with Clinical Pathological Characteristics and Prognosis
曹非 1张国耀 1孙文洁2
作者信息
- 1. 462600 河南省漯河市中心医院
- 2. 450052 郑州大学第一附属医院
- 折叠
摘要
目的 探讨HHLA2与转录因子FOXO3A在非小细胞肺癌组织中表达水平及与其临床预后的关系.方法 选取147例接受检查治疗的非小细胞肺癌患者作为研究对象,采用免疫组化法对癌组织及癌旁组织中HHLA2和FOXO3A表达进行测定.多因素cox回归分析非小细胞肺癌患者的预后相关因素.结果 HHLA2在非小细胞肺癌组织中呈现高表达(57.1％vs 42.9％),FOX3OA蛋白阳性率低于癌旁组织(34.7％vs 65.3％)(P＜0.05);HHLA2蛋白与TNM分期、淋巴结状态和复发显著相关,FOX3OA仅仅与TNM分期和淋巴结状态有关;单因素分析显示:TMN分期为Ⅲ～Ⅳ期、淋巴结转移、复发、HHLA2阳性和FOXO3A阴性与患者5年生存率相关;多因素分析显示:TMN分期为Ⅲ～Ⅳ期、淋巴结转移、HHLA2阳性、FOXO3A阴性是影响非小细胞肺癌患者预后的独立危险因素.HHLA2阴性、FOXO3A阳性的非小细胞肺癌患者5年总体生存率明显高于HHLA2阳性、FOXO3A阴性患者(P＜0.05).结论 在非小细胞肺癌患者中,HHLA2蛋白表达升高与FOXO3A蛋白表达降低可能是影响其预后的独立危险因素.
Abstract
Objective To investigate the expression levels of HHLA2 and the transcription factor FOXO3A in non-small cell lung cancer(NSCLC)tissues and their relationship with clinical prognosis.Methods A total of 147 NSCLC patients who re-ceived examination and treatment were selected as the study subjects.The expression of HHLA2 and FOXO3A in cancer tissues and adjacent non-cancerous tissues was measured using immunohistochemistry.Multivariate Cox regression analysis was used to i-dentify factors related to the prognosis of NSCLC patients.Results HHLA2 was highly expressed in NSCLC tissues(57.1％vs.42.9％),while the positive rate of FOXO3A protein was lower than that in adjacent tissues(34.7％vs.65.3％)(P＜0.05).HHLA2 protein was significantly associated with TNM stage,lymph node status,and recurrence,while FOXO3A was only associat-ed with TNM stage and lymph node status.Univariate regression analysis confirmed that TNM stage Ⅲ～Ⅳ,lymph node metasta-sis,recurrence,HHLA2 positive and FOXO3A negative were correlated with 5-year survival of patients;Multivariate regression a-nalysis showed that TNM stage Ⅲ～Ⅳ,lymph node metastasis,HHLA2 positive and FOXO3A negative were independent risk fac-tors affecting the prognosis of NSCLC patients.NSCLC patients who were HHLA2-negative and FOXO3A-positive had a signifi-cantly higher 5-year overall survival rate compared to HHLA2-positive and FOXO3A-negative patients(P＜0.05).Conclusion Increased expression of HHLA2 and decreased expression of FOXO3A in NSCLC tissues may be independent risk factors affecting the prognosis of NSCLC patients.
关键词
FOXO3A/HHLA2/非小细胞肺癌/临床病理/预后Key words
FOXO3A/HHLA2/NSCLC/Clinical/Prognosis引用本文复制引用
出版年
2024
NETL
NSTL
万方数据