The Expression of HHLA2 and FOXO3A in NSCLC Tissues and Their Correlation with Clinical Pathological Characteristics and Prognosis
Objective To investigate the expression levels of HHLA2 and the transcription factor FOXO3A in non-small cell lung cancer(NSCLC)tissues and their relationship with clinical prognosis.Methods A total of 147 NSCLC patients who re-ceived examination and treatment were selected as the study subjects.The expression of HHLA2 and FOXO3A in cancer tissues and adjacent non-cancerous tissues was measured using immunohistochemistry.Multivariate Cox regression analysis was used to i-dentify factors related to the prognosis of NSCLC patients.Results HHLA2 was highly expressed in NSCLC tissues(57.1％vs.42.9％),while the positive rate of FOXO3A protein was lower than that in adjacent tissues(34.7％vs.65.3％)(P＜0.05).HHLA2 protein was significantly associated with TNM stage,lymph node status,and recurrence,while FOXO3A was only associat-ed with TNM stage and lymph node status.Univariate regression analysis confirmed that TNM stage Ⅲ～Ⅳ,lymph node metasta-sis,recurrence,HHLA2 positive and FOXO3A negative were correlated with 5-year survival of patients;Multivariate regression a-nalysis showed that TNM stage Ⅲ～Ⅳ,lymph node metastasis,HHLA2 positive and FOXO3A negative were independent risk fac-tors affecting the prognosis of NSCLC patients.NSCLC patients who were HHLA2-negative and FOXO3A-positive had a signifi-cantly higher 5-year overall survival rate compared to HHLA2-positive and FOXO3A-negative patients(P＜0.05).Conclusion Increased expression of HHLA2 and decreased expression of FOXO3A in NSCLC tissues may be independent risk factors affecting the prognosis of NSCLC patients.
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