Expression of Vasculogenic Mimicry and Cripto-1 in Non-small Cell Lung Cancer and Its Clinical Significance
Objective To search for biological factors that might predict invasion,metastasis and prognosis of non-small cell lung cancer(NSCLC).Methods The immunohistochemical method was used to detect the formation of vasculogenic mimicry(VM)and the expression level of Cripto-1 in 145 cases of NSCLC.Results Cripto-1 levels were observably higher in the NSCLC tissues(56.6％)than in the healthy lung tissues(36.6％,P＜0.001).VM was present only in the NSCLC tissues(37.2％vs 0,P＜0.05).Cripto-1 expression was positively correlated with VM formation(P＜0.001).Patients with high levels of Cripto-1 and VM formation had decreased overall survival(OS)(P＜0.001).Moreover,multivariate analysis demonstrated that Cripto-1 upregulation,VM formation,TNM stage,and LNM were independent correlative factors affecting NSCLC prognosis.Con-clusion Cripto-1 and VM levels are significantly elevated in NSCLC tissues and may serve as immune markers to predict inva-sion,metastasis,and prognosis in this cancer.
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