鼻咽癌组织中JAK2、STAT3表达及与其临床病理特征的相关性分析
Expression of JAK2 and STAT3 in Nasopharyngeal Carcinoma Tissue and Their Correlation with Clinical Pathological Characteristics
李蓓 1黄菊芳 1韩俊彩1
作者信息
摘要
目的 分析Janus激酶2(JAK2)、信号传导和转录激活因子3(STAT3)在鼻咽癌组织内的表达及与其临床病理特征的关系.方法 选取59例鼻咽癌患者,采集其癌组织与癌旁正常组织(距肿瘤组织边缘≥3 cm)分别纳入观察组与对照组,采用免疫组化法测定两组的JAK2、STAT3表达;另收集患者的年龄、性别等资料,分析JAK2、STAT3表达与其临床病理特征的关系.结果 观察组JAK2、STAT3阳性表达率高于对照组,有统计学差异(P＜0.05);JAK2、STAT3表达与鼻咽癌患者年龄、性别、吸烟史无关(P＞0.05);与鼻咽癌临床分期、分化程度、淋巴结转移有关(P＜0.05);JAK2、STAT3阳性表达患者的生存率低于JAK2、STAT3阴性表达患者,有统计学差异(P＜0.05).结论 JAK2、STAT3在鼻咽癌组织内呈异常的高表达,两者与患者的临床分期、分化程度、淋巴结转移存在紧密联系,且其表达越高,患者生存率越低.
Abstract
Objective To analyze the expression of Janus kinase 2(JAK2)and signal transduction and transcription ac-tivating factor 3(STAT3)in nasopharyngeal carcinoma tissue and their relationship with clinical and pathological characteristics.Methods 59 patients with nasopharyngeal carcinoma were selected,and their cancer tissue and adjacent normal tissue(≥3 cm from the edge of the tumor tissue)were collected and included in the observation group and the control group,respectively.The expression of JAK2 and STAT3 in both groups was measured by immunohistochemistry;Collected age,gender and other data of pa-tients,and analyzed the relationship between the expression of JAK2 and STAT3 and their clinical and pathological characteris-tics.Results The positive expression rates of JAK2 and STAT3 in the observation group were higher than those in the control group,with statistical differences(P＜0.05);The expression of JAK2 and STAT3 was not associated with age,gender,and smok-ing history in nasopharyngeal carcinoma patients(P＞0.05);Related to clinical staging,differentiation degree,and lymph node metastasis of nasopharyngeal carcinoma(P＜0.05);The survival rate of JAK2 and STAT3 positive expression patients was lower than that of JAK2 and STAT3 negative expression patients,with a statistical difference(P＜0.05).Conclusion JAK2 and STAT3 exhibit abnormally high expression in nasopharyngeal carcinoma tissue,which is closely related to the clinical stage,differ-entiation degree,and lymph node metastasis of patients.The higher their expression,the lower the patient's survival rate.
关键词
鼻咽癌/临床病理特征/相关性/Janus蛋白酪氨酸激酶2/信号传导和转录激活因子3Key words
Nasopharyngeal cancer/Clinical pathological features/Correlation/Janus protein tyrosine kinase 2/Signal transduction and transcriptional activation factor 3引用本文复制引用
出版年
2024
NETL
NSTL
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