Expression of JAK2 and STAT3 in Nasopharyngeal Carcinoma Tissue and Their Correlation with Clinical Pathological Characteristics
Objective To analyze the expression of Janus kinase 2(JAK2)and signal transduction and transcription ac-tivating factor 3(STAT3)in nasopharyngeal carcinoma tissue and their relationship with clinical and pathological characteristics.Methods 59 patients with nasopharyngeal carcinoma were selected,and their cancer tissue and adjacent normal tissue(≥3 cm from the edge of the tumor tissue)were collected and included in the observation group and the control group,respectively.The expression of JAK2 and STAT3 in both groups was measured by immunohistochemistry;Collected age,gender and other data of pa-tients,and analyzed the relationship between the expression of JAK2 and STAT3 and their clinical and pathological characteris-tics.Results The positive expression rates of JAK2 and STAT3 in the observation group were higher than those in the control group,with statistical differences(P＜0.05);The expression of JAK2 and STAT3 was not associated with age,gender,and smok-ing history in nasopharyngeal carcinoma patients(P＞0.05);Related to clinical staging,differentiation degree,and lymph node metastasis of nasopharyngeal carcinoma(P＜0.05);The survival rate of JAK2 and STAT3 positive expression patients was lower than that of JAK2 and STAT3 negative expression patients,with a statistical difference(P＜0.05).Conclusion JAK2 and STAT3 exhibit abnormally high expression in nasopharyngeal carcinoma tissue,which is closely related to the clinical stage,differ-entiation degree,and lymph node metastasis of patients.The higher their expression,the lower the patient's survival rate.
Nasopharyngeal cancerClinical pathological featuresCorrelationJanus protein tyrosine kinase 2Signal transduction and transcriptional activation factor 3
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NSTL
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