Relationship Between Cerebrospinal Fluid β-EP and 3-NT Levels and Postoperative Neurological Injury Degree and Prognosis in Patients with Glioma
Objective To study the relationship between cerebrospinal fluid β-endorphin(β-EP)and 3-nitrotyrosine(3-NT)levels and postoperative neurological injury degree and prognosis in patients with glioma.Methods 76 patients with glioma were selected as the observation group,and 76 subjects without glioma and neurological injury in cerebrospinal fluid specimens were collected as the control group.The levels of cerebrospinal fluid β-EP and 3-NT were detected in the 2 groups.National Insti-tutes of Health Stroke Scale(NIHSS)was used to evaluate the degree of neurological injury in the observation group,and the differences in cerebrospinal fluid β-EP and 3-NT levels were compared between the 2 groups,and the relationship between each factor and postoperative neurological injury degree and prognosis in patients with glioma was studied.Results The levels of cere-brospinal fluid β-EP and 3-NT in the observation group were higher compared with those in the control group(P＜0.05).The lev-els of β-EP and 3-NT in cerebrospinal fluid in patients with moderate and severe glioma were higher than those in patients with mild glioma(P＜0.05),and the levels in patients with severe glioma were higher than those in patients with moderate glioma(P＜0.05).The levels of cerebrospinal fluid β-EP and 3-NT were positively correlated with the degree of neurological injury in pa-tients with glioma(P＜0.05),and cerebrospinal fluid β-EP was positively correlated with 3-NT(P＜0.05).When the cut-off val-ue of cerebrospinal fluid β-EP was＞42.03 ng/L,the Youden index,area under the curve(AUC),sensitivity and specificity were 0.586,0.746,66.67％and 91.94％in predicting prognosis of glioma.When the cutoff value of cerebrospinal fluid 3-NT was＞8.93 μg/L,the Youden index,AUC,sensitivity and specificity were 0.459,0.753,55.56％and 90.32％respectively.Conclu-sion The levels of β-EP and 3-NT in cerebrospinal fluid of patients with glioma are increased with the severity of neurological injury,and the above 2 levels are the causes of poor prognosis,and may be effective biomarkers for evaluating the progression of glioma.
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