Comparison of Clinical Efficacy of Chitosan and Sodium Hyaluronate Intravesical Instillation in the Treatment of Radiation Cystitis
Objective To compare the clinical efficacy of intravesical instillation of chitosan and sodium hyaluronate in the treatment of radiation cystitis.Methods A total of 62 patients with radiation cystitis treated were randomly divided into chi-tosan group(n=31)and sodium hyaluronate group(n=31).Chitosan treatment group was treated with chitosan bladder instilla-tion and sodium hyaluronate treatment group was treated with sodium hyaluronate bladder instillation on the basis of symptomatic treatment.The patients in the 2 groups received continuous treatment for 3 months.The changes of hematuria,bladder irritation,cystoscopy and quality of life were observed and compared between the two groups after treatment.Results In the chitosan treat-ment group,the effective rates of hematuria,bladder irritation,cystoscopy and quality of life were 93.55％,90.91％,93.55％and(89.65±4.56),respectively.The effective rates of hematuria,bladder irritation,cystoscopy and quality of life in sodium hyalur-onate group were 74.19％,63.64％,74.19％and(84.15±5.93)respectively.The evaluation index of chitosan group was higher than that of sodium hyaluronate group(P＜0.05).Conclusion Chitosan is more valuable than sodium hyaluronate in reducing the degree of hematuria,relieving the symptoms of bladder irritation,improving cystoscopic performance,and enhancing the quality of life in the bladder perfusion treatment of radiation cystitis.
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