Clinical Observation of TACE Combined with Radiofrequency Ablation in the Treatment of Recurrent Liver Cancer
Objective To investigate the efficacy of hepatic arterial chemoembolization(TACE)combined with radiofre-quency ablation(RFA)in the treatment of recurrent hepatocellular carcinoma.Methods 70 patients with recurrent hepatocellu-lar carcinoma were selected and randomly divided them into combination group(35 cases)and control group(35 cases)accodring to random number table method.The control group was treated with TACE,while the combined group was treated with TACE com-bined with RFA.Compare the levels of immune function[natural killer(NK)cells,T lymphocyte differentiation group 4+(CD4+),CD8+],liver function[aspartate aminotransferase(AST),alanine aminotransferase(ALT)]and tumor markers[carci-noembryonic antigen(CEA),glycoprotein antigen 199(CA199),and alpha fetoprotein(AFP)]between the two groups before and after treatment.Compare the clinical efficacy and survival period between the two groups.Results After treatment,the cells lev-els of CD3+,CD4+,and NK in both groups increased(P＜0.05),and the combined group was higher than the control group(P＜0.05).After treatment,the serum levels of CEA,AFP,and CA199 in both groups decreased(P＜0.05),and the combined group was lower than the control group(P＜0.05).After treatment,the serum levels of ALT and AST in both groups decreased(P＜0.05),and the combined group was lower than the control group(P＜0.05).The effective rate of the combined group was higher than that of the control group(P＜0.05).The survival period and survival rate in the combined group were higher than those in the control group(P＜0.05).Conclusion TACE combined with RFA can significantly improve the immune function and liver function of patients with recurrent hepatocellular carcinoma,reduce the level of tumor markers,mprove the curative effect and survival rate,and prolong the survival period.
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