Relationship between Serum CEA and CA1 25 Expression and Clinicopathological Features and Neoadjuvant Chemotherapy Effect in Advanced Breast Cancer
Objective To investigate the relationship between the expression of serum CEA and CA1 25 and the clinico-pathological features and the effect of neoadjuvant chemotherapy in advanced breast cancer.Methods 55 patients with advanced breast cancer were selected as the case group,and 30 healthy volunteers were selected as the control group.The case group re-ceived neoadjuvant chemotherapy,and was further divided into drug-resistant group and sensitive group according to chemotherapy response.CEA and CA125 levels were detected by automatic chemiluminescence immunoanalyzer.The differences of serum CEA and CA125 expression in the case group with different clinicopathological characteristics were compared,and the differences of se-rum CEA and CA125 expression in the drug-resistant group and the sensitive group were compared.The factors affecting the effect of neoadjuvant chemotherapy in the case group were analyzed by multivariate Logistic stepwise regression,and receiver operating characteristic(ROC)curve was drawn.To analyze the value of CEA and CA125 in predicting the effect of neoadjuvant chemother-apy in case group.Results There were significant differences in the expression levels of CEA and CA125 in serum between case group and control group(P＜0.05).There were significant differences in the expression of CEA and CA125 in different tumor di-ameter,WHO grade,Ki-67 proliferation index,clinical stage,molecular type and metastatic status(P＜0.05),but there were no significant differences in different age,menopausal status,surgical method,ER,PR and HER-2(P＞0.05).The levels of CEA and CA125 in drug-resistant group were higher than those in sensitive group(P＜0.05).Tumor diameter(＞2 cm),WHO grade(Ⅲ),Ki-67 proliferation index(≥20),clinical stage(Ⅳ),molecular classification(triple negative type,HER-2 overexpression type)and metastasis were risk factors affecting the efficacy of neoadjuvant chemotherapy in advanced breast cancer patients(P＜0.05).The sensitivity(75.66％)and specificity(85.63％)of serum CEA and CA125 combined predicted the efficacy of neoad-juvant chemotherapy in advanced breast cancer patients were higher than that of single detection index(P＜0.05).Conclusion Serum CEA and CA125 levels are closely related to clinicopathological features and the effect of neoadjuvant chemotherapy in pa-tients with advanced breast cancer,and can be used as valuable indicators to evaluate the effect of neoadjuvant chemotherapy in patients with advanced breast cancer.
Breast cancerCEACA1 25Clinicopathological featuresNeoadjuvant chemotherapy
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