The Synergistic Anticancer Effect of Histone Methyl transferase 2 Inhibitor BAY-598 and Doxorubicin in Osteosarcoma
Objective To investigate the synergistic anticancer effect of BAY-598,a histone methyltransferase 2 inhibi-tor,and doxorubicin in osteosarcoma.Methods The inhibitory effects of the 2 drugs,either alone or in combination,on the malig-nant characteristics of osteosarcoma cells were assessed through experiments involving cell proliferation,migration,invasion,and colony formation.Flow cytometry was employed to detect cell apoptosis and the cell cycle.Results Combined treatment with his-tone methyltransferase 2 inhibitors and doxorubicin synergistically inhibited cell growth,migration,and invasion,inducing cell ap-optosis and leading to cell cycle arrest in osteosarcoma cells.Further mechanistic exploration suggested that the JAK-STAT signa-ling pathway might be a key player in this synergistic effect.Conclusion Histone methyltransferase 2 inhibitors and doxorubicin have synergistic anticancer effects on osteosarcoma,and their combined use may be a promising treatment strategy for osteosarco-ma.
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维普
