Expression of MMP9,AEG-1 and EphA7 Proteins in Middle Ear Squamous Cell Carcinoma and Their Clinical Significance
Objective To investigate the expression and significance of matrix metalloproteinase-9(MMP-9),astrocyte promoter gene-1(AEG-1)and tyrosine protein kinase receptor A7(EphA7)in middle ear squamous cell carcinoma.Methods 65 patients with middle ear squamous cell carcinoma were selected as the study subjects,all of whom underwent surgical treat-ment.The expression of MMP-9,AEG-1 and EphA7 protein in cancer tissues and adjacent normal tissues were detected during the operation,and the above expression differences were compared between cancer tissues and adjacent normal tissues.The relation-ship between the expression of MMP-9,AEG-1 and EphA7 protein and the pathological characteristics of age,sex,tumor stage,lymph node metastasis and differentiation was analyzed.Results The positive expression rates of MMP-9,AEG-1 and EphA7 proteins in cancer tissues were higher than those in adjacent normal tissues,with statistical significance(P＜0.05).Patients with positive expression of MMP-9,AEG-1 and EphA7 protein had higher proportion of stage Ⅲ～Ⅳ and lymph node metastasis than those with negative expression,and the difference was statistically significant(P＜0.05).Conclusion MMP-9,AEG-1 and E-phA7 proteins are highly expressed in middle ear squamous cell carcinoma,and their expression is closely related to tumor stage and lymph node metastasis,which may be a new target for clinical treatment.
万方数据
维普
