Objective To study the expression of epidermal growth factor receptor(EGFR),GATA-3 and E-cad in breast cancer tissues and their relationship with prognosis.Methods 89 patients with breast cancer were selected.The cancerous tissue and normal tissue(≥ 3 cm away from the edge of the focus)of all patients were collected during the operation,and they were respectively included in the observation group and the control group.The positive expression of EGFR,GATA-3,E-Cad in the two groups were statistically compared.Follow up for another year to compare the survival rates of patients with different EG-FR,GATA-3,and E-Cad expressions.Results The positive expression rates of EGFR and GATA-3 in the observation group were higher than those in the control group,while the positive expression rates of E-Cad were lower than those in the control group,with a statistically significant difference(P＜0.05);The expressions of EGFR,GATA-3,and E-Cad were correlated with the degree of differentiation,lymph node metastasis,and clinical stage of patients,and the differences were statistically significant(P＜0.05);The survival rate of EGFR and GATA-3 positive expression patients was lower than that of negative expression patients,and the survival rate of E-Cad negative expression patients was lower than that of positive expression patients,with statistical significance(P＜0.05).Conclusion EGFR and GATA-3 are highly expressed in breast cancer tissues,while E-Cad is low expressed.These expressions are closely related to the survival rate of breast cancer patients.
关键词
乳腺癌/表皮生长因子受体/GATA结合蛋白3(GATA-3)/上皮性钙黏附蛋白/预后
Key words
Breast cancer/Epidermal growth factor receptor/GATA-Binding Protein 3(GATA-3)/Epithelial calcium ad-hesive protein/Prognosis
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