Objective To investigate the phosphatase and tensin homolog deleted on chromosome ten(PTEN),matrix metalloproteinase-2(MMP-2)and protein kinase B(AKT)deleted on chromosome 10 in breast cancer tissues and their relation-ship with clinicopathological characteristics.Methods 63 patients with breast cancer were selected to collect their cancerous tis-sues and normal adjacent tissues(≥3 cm away from the edge of the lesion).The expressions of PTEN,MMP-2 and AKT were de-tected by immunohistochemical method.Collect age,gender and other data of patients,and analyze the relationship between PTEN,MMP-2,AKT expression and clinical pathological characteristics of patients.Results The positive expression rates of MMP-2 and AKT in the cancerous tissues were higher than normal adjacent tissues,while the positive expression rates of PTEN in the cancerous tissues were lower than normal adjacent tissues,with statistical differences(P＜0.05);The expression of PTEN,MMP-2 and AKT was not related to the age and tumor location of breast cancer patients(P＞0.05);There was a statistically sig-nificant difference in the histological grading and lymph node metastasis of patients(P＜0.05).Conclusion PTEN,MMP-2 and AKT are abnormally expressed in breast cancer tissue,and is related to the histological grading and lymph node metastasis of pa-tients.
关键词
乳腺癌/第10号染色体缺失的磷酸酶和张力蛋白同源基因/基质金属蛋白酶-2/蛋白激酶B/临床病理特征
Key words
Breast cancer/Phosphatase and tensin homolog deleted on chromosome ten/Matrix metalloproteinase-2/Pro-tein kinase B/Clinical pathological features
维普
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