Correlation Analysis of VEGF and Its Receptors,CXCL10,PDK1 Expression with Recur-rence and Metastasis in Nasopharyngeal Carcinoma Tissue
Objective To investigate the relationship between the expression of vascular endothelial growth factor(VEGF),its receptor,chemokine ligand 10(CXCL10),pyruvate dehydrogenase kinase-1(PDK1)and recurrence and metastasis in nasopharyngeal carcinoma.Methods The clinical data of 89 patients with nasopharyngeal carcinoma were retrospectively ana-lyzed.The expression of VEGF,VEGF receptor-2(VEGFR-2),CXCL10 and PDK1 were detected by immunohistochemical SP method before radiotherapy,and the differences of expression between tumor tissues and adjacent normal tissues were compared.The expression of VEGF and its receptor,CXCL10 and PDK1 among patients with different age,sex,tumor stage and lymph node metastasis were compared.After 2 years of follow-up,the recurrence and metastasis and their relationship with the expression of VEGF and its receptor,CXCL10 and PDK1 were analyzed.Results The positive expressions of VEGF and receptor,CXCL10 and PDK1 in tumor tissues were higher than those in adjacent normal tissues,and the differences were statistically significant(P＜0.05).The positive expression rates of VEGF,receptor,CXCL10 and PDK1 in patients with clinical stage Ⅲ to Ⅳ and lymph node metastasis were higher than those in patients with clinical stage Ⅰ to Ⅱ and no lymph node metastasis,and the difference was statistically significant(P＜0.05).After 2 years of follow-up,there were 27 recurrence and metastasis in 89 cases,and the re-currence and metastasis rate was 30.34％(27/89).The positive expression rates of VEGF and receptor,CXCL10 and PDK1 in patients with recurrence and metastasis were higher than those without recurrence and metastasis,and the difference was statisti-cally significant(P＜0.05).Conclusion VEGF and its receptor,CXCL10 and PDK1 are highly expressed in nasopharyngeal carcinoma tissues,and their high expression is closely related to tumor recurrence and metastasis.Clinical attention should be paid to improve early treatment.
万方数据
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