Correlation Between LMP-1,Bel-2 and Tumor Invasion and Metastasis in Tissues of Nasopharyngeal Carcinoma
Objective To analyze the relationship between latent membrane protein-1(LMP-1)and B-lymphocyte tumor(Bcl-2)genes and their invasion and metastasis in nasopharyngeal carcinoma tissue.Methods 120 NPC patients were selected for the study,and lesion tissues were collected using nasal endoscopy.The expression of LMP-1 and Bcl-2 in the tissues was de-tected using immunohistochemistry.The degree of NPC tumor invasion and metastasis was evaluated based on TNM staging,and the relationship between LMP-1,Bcl-2 and NPC invasion and metastasis was analyzed.Results Among the 120 NPC patients,86 were LMP-1 positive,accounted for 71.67％,and 90 were Bcl-2 positive,accounted for 75.00％;The proportion of EBV-DNA positivity was high in LMP-1 and Bcl-2 positive patients,and the difference was statistically significant compared to LMP-1 and Bcl-2 negative patients(P＜0.05).The positive expression rates of LMP-1 and Bcl-2 in patients with different stages of TNM were compared,and the differences were statistically significant(P＜0.05).Using chi square Phi and Cramer's Ⅴ coefficient tests,it was found that the expression of LMP-1 and Bcl-2 in NPC tissues was significantly correlated with tumor invasion and me-tastasis(P＜0.05).Conclusion The positive expression rates of LMP-1 and Bcl-2 are generally high in NPC tissues,and the positive expression of LMP-1 and Bcl-2 is related to tumor invasion and metastasis.
Nasopharyngeal carcinomaLatent membrane protein-1B-cell lymphocytoma-2 geneTumor invasion and metastasis
万方数据
维普
