摘要
目的 研究细胞核增殖抗原(Ki-67)、SOX2、C-Myc、p63在食管鳞状细胞癌组织内的表达及其临床意义.方法 选取97例食管鳞状细胞癌患者,采集其癌组织与癌旁正常组织(距癌组织边缘≥3 cm),以免疫组织化学法检测两样本Ki-67、SOX2、C-Myc、p63表达;另收集患者的年龄等资料,分析Ki-67、SOX2、C-Myc、p63与患者各项病理特征之间的关系.结果 癌组织Ki-67、SOX2、C-Myc、p63阳性表达率高于癌旁正常组织,差异有统计学意义(P＜0.05).Ki-67、SOX2、C-Myc、p63阳性表达与患者的年龄、性别无关(P＞0.05);与临床分期、淋巴结转移、分化程度有关(P＜0.05).结论 Ki-67、SOX2、C-Myc、p63在食管鳞状细胞癌组织内呈异常高表达,四者表达与患者的临床分期、淋巴结转移、分化程度有关,参与疾病的发生与发展.
Abstract
Objective To study the expression and clinical significance of nuclear proliferating antigen(Ki-67),SOX2,C-Myc,and p63 in esophageal squamous cell carcinoma tissue.Methods 97 patients with esophageal squamous cell carcinoma were selected,and their cancer tissues and adjacent normal tissues(≥ 3 cm away from the edge of the cancer tissue)were collect-ed.The expression of Ki-67,SOX2,C-Myc,and p63 in the 2 samples was detected using immunohistochemistry;Collect age and other data of patients,and analyze the relationship between Ki-67,SOX2,C-Myc,p63 and various pathological characteristics of patients.Results The positive expression rates of Ki-67,SOX2,C-Myc,and p63 in cancer tissues were higher than those in nor-mal tissues adjacent to cancer,with statistical significance(P＜0.05).The positive expression of Ki-67,SOX2,C-Myc,and p63 was not related to the age and gender of patients(P＞0.05).Conclusion Ki-67,SOX2,C-Myc,and p63 are abnormally high ex-pressed in esophageal squamous cell carcinoma tissue,and their expression is related to the clinical stage,lymph node metastasis,and differentiation degree of patients,participating in the occurrence and development of the disease.
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