Expression and Clinical Significance of Ki-67,SOX2,C-Myc,and p63 in Esophageal Squamous Cell Carcinoma Tissue
Objective To study the expression and clinical significance of nuclear proliferating antigen(Ki-67),SOX2,C-Myc,and p63 in esophageal squamous cell carcinoma tissue.Methods 97 patients with esophageal squamous cell carcinoma were selected,and their cancer tissues and adjacent normal tissues(≥ 3 cm away from the edge of the cancer tissue)were collect-ed.The expression of Ki-67,SOX2,C-Myc,and p63 in the 2 samples was detected using immunohistochemistry;Collect age and other data of patients,and analyze the relationship between Ki-67,SOX2,C-Myc,p63 and various pathological characteristics of patients.Results The positive expression rates of Ki-67,SOX2,C-Myc,and p63 in cancer tissues were higher than those in nor-mal tissues adjacent to cancer,with statistical significance(P＜0.05).The positive expression of Ki-67,SOX2,C-Myc,and p63 was not related to the age and gender of patients(P＞0.05).Conclusion Ki-67,SOX2,C-Myc,and p63 are abnormally high ex-pressed in esophageal squamous cell carcinoma tissue,and their expression is related to the clinical stage,lymph node metastasis,and differentiation degree of patients,participating in the occurrence and development of the disease.
Esophageal squamous cell carcinomaImmunohistochemical methodClinical pathological features
万方数据
维普
