Application Value of Digital Subtraction Angiography Perfusion Imaging Technology in Short-term Efficacy Evaluation of DEB-TACE in Patients with Advanced Liver Cancer
Objective To explore the application value of digital subtraction angiography(DSA)perfusion imaging tech-nology in short-term efficacy evaluation of drug eluting beads-transcatheter arterial chemoembolization(DEB-TACE)in patients with advanced liver cancer.Methods 164 patients with advanced hepatocellular carcinoma who underwent DEB-TACE were se-lected as study subjects,and the patients were divided into OR group(complete remission+partial remission)and non-OR group(stable disease+disease progression)according to their short-term postoperative outcomes.All patients underwent DSA perfusion imaging technology testing after surgery;receiver operating characteristic(ROC)curve was applied to analyze the diagnostic value of DSA perfusion imaging technology for short-term outcomes after DEB-TACE surgery.Results 164 patients were treated after DEB-TACE,49 in complete remission,55 in partial remission,53 in stable disease,and 7 in disease progression.The arrival time of patients in the non OR group was obviously lower than that in the OR group(P＜0.05),while the peak time,filling rate,curve width,and average passage time were obviously higher than those in the OR group(P＜0.05).According to the receiver operating characteristic,the area under the curve(AUC)of arrival time in diagnosing short-term effect after DEB-TACE was 0.891,the sen-sitivity was 74.12％,and the specificity was 88.47％.The AUC of peak time in diagnosing short-term effects after DEB-TACE was 0.900,with a sensitivity of 76.37％and a specificity of 85.75％.The AUC of filling rate in diagnosing short-term effects af-ter DEB-TACE was 0.875,sensitivity was 78.67％,and specificity was 83.78％.The AUC of curve width in diagnosing short-term effects after DEB-TACE was 0.859,the sensitivity was 79.67％,and the specificity was 81.75％.The AUC of average passage time in diagnosing short-term effects after DEB-TACE was 0.885,the sensitivity was 80.24％,and the specificity was 78.54％.The AUC of the five combination in diagnosing short-term effects after DEB-TACE was 0.993,the sensitivity was 93.24％,and the specificity was 75.34％.Combined diagnosis of the five is better than separate diagnosis of each(Zcombination vs arrival time=4.078,Zcombination vs peak time=3.443,Zcombination vs filling rate=4.068,Zcombination vs curve width=4.466,Zcombination vs average passage time=3.723,all P＜0.05).Conclusion DSA perfusion imaging technology has good application value in short-term efficacy evaluation of late stage liver cancer patients after DEB-TACE surgery,and can provide more objective basis.
万方数据
维普
